DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zkscan5

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_057892.2	Gene:	Zkscan5 / 22757	MGIID:	107533	Length:	819	Species:	Mus musculus

Alignment Length:	584	Identity:	127/584 - (21%)
Similarity:	195/584 - (33%)	Gaps:	237/584 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VGPVEVEQRPPEKKGSETATKLEPDVDPDE-----AEQEPEHDEEDEDVDLDESHY---AEADDA 153
            |..:|..||..|::..:.||  .|:|.|.:     |.||            ..||.   .||...
Mouse   122 VAVIESIQRELEERRQQIAT--SPEVLPQKMVPPGATQE------------SFSHQCLPVEAQPE 172

  Fly   154 AETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEE-VYDVYETYEGDLIPDQGYDHEMA 217
            .|:|     :.:|:..|..|:... |.:|:.|...|.::.: ...:.:|            .::|
Mouse   173 RESQ-----NLLEENALPVLQVSS-VPLKDSQELTDSLLSDGPQKLVKT------------EDVA 219

  Fly   218 DQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKS-----------------V 265
            |.|:|.:..|..:||| ....|...:.::|.|   ::|..::.|.:.                 |
Mouse   220 DVAVSFILEEWAHLDQ-SQKSLGRDSRKEDCE---STTPVDYEPKEGNLEFTVQQVSDAADPHWV 280

  Fly   266 RASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSIKSEKDIS 330
            .|....:|..:|   |.....|.....|.......|. |||.:           |..::|..|::
Mouse   281 AAERTEKNGVQR---PESGEVSDLKDMVPRWQVNPTS-GNPRQ-----------KRPLRSGPDVN 330

  Fly   331 IGEVLARKHSGIKTKG--GHKILLGD--------------------KKEFKYICDVCGNMYPSQS 373
                  ||.   |:.|  ||:  .||                    :|.||  |..||..|..:.
Mouse   331 ------RKQ---KSNGERGHR--CGDCGKFFLQASNFIQHRRIHTGEKPFK--CGECGKSYNQRV 382

  Fly   374 RLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAF------------- 425
            .||:|.:||:|.||::|::||..|..:..|.:|.:.|:|.|||.|:.|..:|
Mouse   383 HLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQHHSVHSGERPYGCNECGKSFGRHSHLIEHLKRH 447

  Fly   426 ----------------------------ADLS-----TRN------------------------- 432
                                        |||.     .||
Mouse   448 FREKSQRCSDRRSKNTKLNIKQIPGLSEADLELSGEVQRNACQAEGHSEGCEHQDGQQGVVMKET 512

  Fly   433 --------------------------------------------KHHRIHTNERPYECDVCHKTF 453
                                                        :|.||||.|:|:.|:.|.|::
Mouse   513 LGQSSSKRTDCNEFSYVHKKSSPGERPHQCNECGKSFIQSAHLIQHRRIHTGEKPFRCEECGKSY 577

  Fly   454 TYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHER----------RGQSARESVAG 507
            .....|..|..:||||||:.|.:|||.|.....|..|:.:|.|          :|...|..:||
Mouse   578 NQRVHLTQHHRVHTGEKPYACHLCGKAFRVRSHLVQHQSVHSRERPFKCNECGKGFGRRSHLAG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	12/23 (52%)
		COG5048	386..>447	CDD:227381	28/175 (16%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/63 (16%)
		C2H2 Zn finger	418..438	CDD:275368	10/134 (7%)
		zf-H2C2_2	432..455	CDD:290200	11/91 (12%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
Zkscan5	NP_057892.2	SCAN	47..155	CDD:128708	10/34 (29%)
		SCAN	47..134	CDD:280241	4/11 (36%)
		KRAB	220..251	CDD:279668	10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..263		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..340		16/80 (20%)
		COG5048	323..744	CDD:227381	75/332 (23%)
		C2H2 Zn finger	343..363	CDD:275368	2/19 (11%)
		zf-H2C2_2	355..380	CDD:290200	7/26 (27%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..406	CDD:290200	11/22 (50%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	3/19 (16%)
		zf-C2H2	540..562	CDD:278523	2/21 (10%)
		C2H2 Zn finger	542..562	CDD:275368	2/19 (11%)
		zf-H2C2_2	554..579	CDD:290200	10/24 (42%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		zf-H2C2_2	582..605	CDD:290200	12/22 (55%)
		C2H2 Zn finger	598..618	CDD:275368	7/19 (37%)
		C2H2 Zn finger	626..646	CDD:275368	4/16 (25%)
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	710..730	CDD:275368
		C2H2 Zn finger	766..786	CDD:275368
		zf-H2C2_2	778..802	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050