DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF485

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	176	Identity:	70/176 - (39%)
Similarity:	94/176 - (53%)	Gaps:	19/176 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 RKHSGIK----TKGG------------HKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGV 385
            |.|||.|    .|.|            .||..|:|   .|.|:.||..:...|.|..|.::|:|.
Human   262 RIHSGEKPFKCNKCGRAFRDNSTVLEHQKIHTGEK---PYQCNECGKAFRKSSTLISHQRMHTGE 323

  Fly   386 KPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCH 450
            ||:.|..||..|..:...|.|..||:||:||:|..|..||...||...|.||||.|:||.|..|.
Human   324 KPYHCSKCGKSFRYSSSFAGHQKTHSGNKPYQCRDCGKAFTKSSTLTGHQRIHTGEKPYHCKKCG 388

  Fly   451 KTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHER 496
            |.|.:::.|..|:.:||||||:.|:.|||.||::..|:.|:.||.:
Human   389 KAFRHSSGLVEHQRLHTGEKPYKCNECGKAFPRSSALKQHKKIHNK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<124..361	CDD:227381	36/101 (36%)
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368
		zf-H2C2_2	229..253	CDD:290200
		C2H2 Zn finger	244..264	CDD:275368	1/1 (100%)
		zf-H2C2_2	256..279	CDD:290200	7/16 (44%)
		C2H2 Zn finger	272..292	CDD:275368	3/19 (16%)
		zf-H2C2_2	287..307	CDD:290200	8/22 (36%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..337	CDD:290200	10/23 (43%)
		C2H2 Zn finger	328..348	CDD:275368	6/19 (32%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..393	CDD:290200	12/20 (60%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..419	CDD:290200	12/21 (57%)
		C2H2 Zn finger	412..432	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910