DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF675

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	522	Identity:	129/522 - (24%)
Similarity:	197/522 - (37%)	Gaps:	151/522 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLQQPKEPM------ASIFNDDSEKD---LTHM------IRECGG-----VPIKQFDHYPDKI-- 68
            ||...:..|      ..:||..|..|   :.||      .:|||.     ..:.:.:....|:
Human   135 CLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNF 199

  Fly    69 --CEKCFKVLKMAFKFRE-----TCQRSY------GHLRQFVGPVEVEQRPPEKKGSETATKLEP 120
              ||:|.|.:..:.|..:     ||::.|      ....||....|.::
Human   200 CKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKK---------------- 248

  Fly   121 DVDPDEAEQEPEHDEEDEDVDLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV--KN 183
                |.|.::|...||........||                          |...:|:|.  |.
Human   249 ----DYAREKPYKCEECGKAFNQSSH--------------------------LTTHKIIHTGEKP 283

  Fly   184 EQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELS----------AEIEYLDQV---- 234
            .:.||.|.....:....|::.....:|.|..|...:|.::.|          .|..|..:.
Human   284 YKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKA 348

  Fly   235 --EHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNPRRSATSTASVAVESST 297
              ...:|||  |:     ::::.|:.:...:..:|...:.|.|:.|           .:..|...
Human   349 FNRSSKLTE--HK-----NIHTGEQPYKCEECGKAFNRSSNLTEHR-----------KIHTEEKP 395

  Fly   298 SKTTDRGNPLKVRRGNSDSAGSKMSIKSEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYIC 362
            .|..:.|.                              |.|||...|.  ||.:...:|.:|  |
Human   396 YKCKECGK------------------------------AFKHSSALTT--HKRIHTGEKPYK--C 426

  Fly   363 DVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFAD 427
            :.||..:...|:||||.|:|:|.||::||.||..|.|:.:|..|...|:|..||||..|..||..
Human   427 EECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKH 491

  Fly   428 LSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRV 492
            .|:...|.||||.|:||:|:.|.|.|:.::.|..||:|||||||:.|:.|.|.|.|:..|..|:.
Human   492 SSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKK 556

  Fly   493 IH 494
            ||
Human   557 IH 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	21/103 (20%)
		C2H2 Zn finger	362..382	CDD:275368	9/19 (47%)
		zf-H2C2_2	375..399	CDD:290200	14/23 (61%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	118/484 (24%)
		C2H2 Zn finger	174..194	CDD:275370	3/19 (16%)
		C2H2 Zn finger	202..222	CDD:275368	5/19 (26%)
		C2H2 Zn finger	230..250	CDD:275368	3/39 (8%)
		C2H2 Zn finger	258..278	CDD:275368	6/45 (13%)
		zf-H2C2_2	270..295	CDD:290200	8/50 (16%)
		C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	3/19 (16%)
		zf-H2C2_2	327..351	CDD:290200	2/23 (9%)
		C2H2 Zn finger	342..362	CDD:275368	4/26 (15%)
		C2H2 Zn finger	370..390	CDD:275368	4/30 (13%)
		zf-H2C2_2	382..407	CDD:290200	7/65 (11%)
		C2H2 Zn finger	398..418	CDD:275368	8/51 (16%)
		zf-H2C2_2	410..435	CDD:290200	8/28 (29%)
		C2H2 Zn finger	426..446	CDD:275368	9/19 (47%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		zf-H2C2_2	494..519	CDD:290200	12/24 (50%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000