DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4936 and ZNF721

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	531	Identity:	131/531 - (24%)
Similarity:	197/531 - (37%)	Gaps:	138/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DLTHMIRECGGVPIKQFDH-----YPDKI--------CEKCFKVLKMAFKFRETCQRSYGHLRQF 96
            |..:..:|||    |.|.|     ..:||        |::|.||:..:..|.:       |.|..
Human   442 DKPYKCKECG----KAFIHSLHLNKHEKIHTGKKPYKCKQCGKVITSSSSFAK-------HKRIH 495

  Fly    97 VG--PVEVEQRPPEKKGSETATK---LEPDVDPDEAE---------------------QEPEHDE 135
            .|  |.|..:.......|.|.||   :.....|...|                     ::|...|
Human   496 TGEKPFECLECGKAFTSSTTLTKHRRIHTGEKPYTCEVCGKAFRQSAILYVHRRIHTGEKPYTCE 560

  Fly   136 E-----DEDVDL---DESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV-----KNEQVE 187
            |     .:..:|   ...|..|.....|..|..|      |...:|.:.:.:|.     |.|:..
Human   561 ECGKTFRQSANLYVHRRIHTGEKPYKCEECGKAF------GRYTDLNQHKKIHTGEKLYKCEECG 619

  Fly   188 EDGI-IEEVYDVYETYEGDLIPDQGYDHEMADQAL---SELSAEIEYLDQVEHDQLTESAHEDDA 248
            :|.: ..::....:.|.|    ::.|..|...:|.   ::|:...:.|...:..:..|.......
Human   620 KDFVWYTDLNQQKKIYTG----EKPYKCEECGKAFAPSTDLNQHTKILTGEQSYKCEECGKAFGW 680

  Fly   249 EVDLN------STEEEFVPSKSVRASIHARN-ATKRRVNPRRSATSTASVAVESSTSKTTDRGNP 306
            .:.||      :.|:.:...:..:|...:|| .|.|||:.|            ....|..|||.
Human   681 SIALNQHKKIHTGEKPYKCEECGKAFSRSRNLTTHRRVHTR------------EKPYKCEDRGR- 732

  Fly   307 LKVRRGNSDSAGSKMSIKSEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPS 371
                     |.|...::...|.|..|:.|                        |.|..||.::..
Human   733 ---------SFGWSTNLNEYKKIHTGDKL------------------------YKCKECGKVFKQ 764

  Fly   372 QSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHR 436
            .|.|..|.|:|:|.||::|:.||.....:...|:|...|||.:|:||..|..||...:|..||.|
Human   765 SSHLNRHEKIHTGKKPYKCKECGKVITSSSSFAKHKRIHTGEKPFKCLECGKAFTSSTTLTKHRR 829

  Fly   437 IHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHERR---- 497
            |||.|:||.|:.|.|.|..:..|..|:.|||||||:.|..|||.|.|:..|..|:.||...
Human   830 IHTGEKPYTCEECGKAFRQSAILYVHRRIHTGEKPYTCGECGKTFRQSANLYAHKKIHTGEKPYT 894

  Fly   498 ----GQSARES 504
                |::.|:|
Human   895 CGDCGKTFRQS 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	15/62 (24%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	26/60 (43%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	13/22 (59%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	14/60 (23%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		COG5048	442..885	CDD:227381	126/509 (25%)
		C2H2 Zn finger	447..467	CDD:275368	7/23 (30%)
		C2H2 Zn finger	475..495	CDD:275368	7/26 (27%)
		zf-H2C2_2	487..512	CDD:290200	6/31 (19%)
		C2H2 Zn finger	503..523	CDD:275368	4/19 (21%)
		zf-H2C2_2	516..540	CDD:290200	4/23 (17%)
		C2H2 Zn finger	531..551	CDD:275368	1/19 (5%)
		zf-H2C2_2	544..568	CDD:290200	3/23 (13%)
		C2H2 Zn finger	559..579	CDD:275368	3/19 (16%)
		zf-H2C2_2	571..596	CDD:290200	6/30 (20%)
		C2H2 Zn finger	587..607	CDD:275368	5/25 (20%)
		C2H2 Zn finger	615..634	CDD:275368	2/18 (11%)
		C2H2 Zn finger	643..663	CDD:275368	3/19 (16%)
		C2H2 Zn finger	671..691	CDD:275368	3/19 (16%)
		zf-H2C2_2	683..708	CDD:290200	4/24 (17%)
		C2H2 Zn finger	699..719	CDD:275368	6/19 (32%)
		C2H2 Zn finger	755..775	CDD:275368	7/19 (37%)
		zf-H2C2_2	767..789	CDD:290200	10/21 (48%)
		C2H2 Zn finger	783..803	CDD:275368	5/19 (26%)
		zf-H2C2_2	795..820	CDD:290200	11/24 (46%)
		C2H2 Zn finger	811..831	CDD:275368	8/19 (42%)
		zf-H2C2_2	824..848	CDD:290200	13/23 (57%)
		C2H2 Zn finger	839..859	CDD:275368	6/19 (32%)
		zf-H2C2_2	852..876	CDD:290200	14/23 (61%)
		C2H2 Zn finger	867..887	CDD:275368	8/19 (42%)
		C2H2 Zn finger	895..915	CDD:275368	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000