DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zfp111

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_579857.1	Gene:	Zfp111 / 170849	RGDID:	620595	Length:	744	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	116/506 - (22%)
Similarity:	179/506 - (35%)	Gaps:	142/506 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KDLTHMIRECG-------GVPIKQFDHYPDK--ICEKCFKVLKMAFKFR--------------ET 85
            |:..:...:||       .:.|.|..|..:|  .||:|.|...::|...              |.
  Rat   318 KEKPYKCDKCGKCFSLNFNLHIHQRVHTGEKPYKCEECGKCFSLSFNLHSHQRVHTGEKPYKCEE 382

  Fly    86 CQRSYGHLRQFV--GPVEVEQRPPEK----KGSETATKLEPDVDPDEAEQEPEHDEEDEDVDLDE 144
            |.:.:.....|.  ..:.::::...:    |||...:.|                :..:.|.:.|
  Rat   383 CGKCFSSASSFQRHRQIHIKEKTLHRDVCGKGSSRDSNL----------------QTHQRVHIQE 431

  Fly   145 SHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLIPD 209
            ..|     ...:.|..|.      ..::|...|.||.                          .:
  Rat   432 KPY-----RCNSCGKSFR------CSMDLNIHRRVHT--------------------------GE 459

  Fly   210 QGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNA 274
            :.|..|:..:..:.||          |.|..|..|.|............|    |..:::|....
  Rat   460 KPYKCEVCGKGFNYLS----------HLQAHEKIHADQKPYKCEYCGRRF----SYSSNLHTHQR 510

  Fly   275 TKRRVNPRRSATSTASVAVESS--------TSKTTDRGNPLKVRRGNS----------------- 314
            ......|.:......|.::.||        |.|...:.|..:.|...:
  Rat   511 VHTGEKPYKCEECGKSFSLASSLQAHQRVQTGKKPFKCNACQKRFSQAWNLQAHQRVHTGEKPYK 575

  Fly   315 -DSAGSKMSIKSEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEH 378
             |:.|.....:|...|.     .|.|:|             :|.||  |:.||..:...|.||.|
  Rat   576 CDTCGKAFGQRSSLQIH-----QRIHTG-------------EKPFK--CEECGKEFSLNSGLTAH 620

  Fly   379 IKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERP 443
            .:||:|.||:||..||..|:.|..|..|...|||.:|::|:.|...|:.:|....|.|:||.|:|
  Rat   621 RRVHTGEKPYECTECGKGFSLASSLRTHQRIHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKP 685

  Fly   444 YECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            |:||.|.|.|:..:.|:.|:.|||||||..|:.|||.|..:..|..||.:|
  Rat   686 YKCDTCGKAFSQKSGLQVHRRIHTGEKPFKCEECGKEFIWSSGLSAHRRVH 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	14/73 (19%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	13/23 (57%)
		COG5048	386..>447	CDD:227381	25/60 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	8/22 (36%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
Zfp111	NP_579857.1	KRAB	8..>54	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<106..396	CDD:227381	15/77 (19%)
		C2H2 Zn finger	212..232	CDD:275368
		C2H2 Zn finger	241..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		zf-H2C2_2	280..305	CDD:290200
		C2H2 Zn finger	296..316	CDD:275368
		COG5048	306..721	CDD:227381	109/489 (22%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	340..360	CDD:290200	7/19 (37%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..389	CDD:290200	2/21 (10%)
		C2H2 Zn finger	380..400	CDD:275368	3/19 (16%)
		C2H2 Zn finger	409..428	CDD:275368	4/34 (12%)
		zf-H2C2_2	420..445	CDD:290200	6/51 (12%)
		C2H2 Zn finger	436..456	CDD:275368	4/25 (16%)
		zf-H2C2_2	448..473	CDD:290200	6/50 (12%)
		C2H2 Zn finger	464..484	CDD:275368	6/29 (21%)
		C2H2 Zn finger	492..512	CDD:275368	3/23 (13%)
		zf-H2C2_2	507..528	CDD:290200	2/20 (10%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	548..568	CDD:275368	2/19 (11%)
		zf-H2C2_2	560..583	CDD:290200	2/22 (9%)
		C2H2 Zn finger	576..596	CDD:275368	5/24 (21%)
		zf-H2C2_2	588..612	CDD:290200	10/43 (23%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		zf-H2C2_2	617..640	CDD:290200	12/22 (55%)
		C2H2 Zn finger	632..652	CDD:275368	7/19 (37%)
		zf-H2C2_2	644..669	CDD:290200	9/24 (38%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		zf-H2C2_2	672..697	CDD:290200	12/24 (50%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		zf-H2C2_2	701..723	CDD:290200	13/21 (62%)
		C2H2 Zn finger	716..736	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000