DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF595

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_872330.1	Gene:	ZNF595 / 152687	HGNCID:	27196	Length:	648	Species:	Homo sapiens

Alignment Length:	518	Identity:	124/518 - (23%)
Similarity:	187/518 - (36%)	Gaps:	130/518 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATSTQKWIVCRVCLQQPKEPMASIFNDDSEKDLTHMIRECGGVPIKQFDHYPDKICEKCFKVLKM 78
            :|:..|...|..|::        :|:..|..: .|.||..|..|.|         |.:|.:...|
Human   138 STTQSKIFQCNTCVK--------VFSKFSNSN-KHKIRHTGEKPFK---------CTECGRSFYM 184

  Fly    79 AFKFRETCQRSYGHLRQFVGPVEVEQRPPEKKGSETATKLEPDVDPDEAEQEPEHDEEDEDVDLD 143
            :            ||.|..|
Human   185 S------------HLTQHTG--------------------------------------------- 192

  Fly   144 ESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV--KNEQVEEDGIIEEVYDVYETYEGDL 206
             .|..|.....|..|..|:..      ..|.|.:.:|.  |....||.|.......|...::...
Human   193 -IHAGEKPYKCEKCGKAFNRS------TSLSKHKRIHTGEKPYTCEECGKAFRRSTVLNEHKKIH 250

  Fly   207 IPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHA 271
            ..::.|..|...:|.:. |..:.     ||.::    |..:.........:.|..|.|:....:.
Human   251 TGEKPYKCEECGKAFTR-STTLN-----EHKKI----HTGEKPYKCKECGKAFRWSTSLNEHKNI 305

  Fly   272 RNATK--------------RRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMS 322
            ....|              |.:|..::..:...........|..::.:.|.:.|          |
Human   306 HTGEKPYKCKECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHR----------S 360

  Fly   323 IKSEKDISIGEVLARKHSGIKTKGGHK-ILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVK 386
            |.||:.:...|...:..:...:...|| |..|:|   .|.|:.||..:...|.|.:|.::|:|.|
Human   361 IHSEQKLYKCEECGKAFTWSSSLNKHKRIHTGEK---PYTCEECGKAFYRSSHLAKHKRIHTGEK 422

  Fly   387 PHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHK 451
            |:.||.||..|.|:..|..|...|:|.:||||..|..||...:|.|:|.:|||.|:||:|:.|.|
Human   423 PYTCEECGKAFNQSSTLILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGK 487

  Fly   452 TFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH--------ERRGQSARESVA 506
            .|.::.:|..||.|||||||:.|..|||.|.|:..|..||.||        |..|::...|.|
Human   488 AFIWSASLNEHKNIHTGEKPYKCKECGKAFNQSSGLIIHRSIHSEQKLYKCEECGKAFTRSTA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	15/72 (21%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	14/21 (67%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	6/28 (21%)
		C2H2 Zn finger	175..194	CDD:275368	7/76 (9%)
		COG5048	198..599	CDD:227381	103/382 (27%)
		C2H2 Zn finger	202..222	CDD:275368	5/25 (20%)
		C2H2 Zn finger	230..250	CDD:275368	4/19 (21%)
		C2H2 Zn finger	258..278	CDD:275368	5/29 (17%)
		C2H2 Zn finger	286..306	CDD:275368	3/19 (16%)
		C2H2 Zn finger	314..334	CDD:275368	2/19 (11%)
		C2H2 Zn finger	342..362	CDD:275368	4/29 (14%)
		C2H2 Zn finger	370..390	CDD:275368	3/19 (16%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..558	CDD:275368	4/13 (31%)
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910