DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF98

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001092096.1	Gene:	ZNF98 / 148198	HGNCID:	13174	Length:	572	Species:	Homo sapiens

Alignment Length:	547	Identity:	135/547 - (24%)
Similarity:	212/547 - (38%)	Gaps:	148/547 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLQQPKEP--------------MASIFNDD----------SEKDLTHMIRECG--GVPIKQFDHY 64
            ||:|.|||              :.|.|..|          .:|.:....::||  .:.::::...
Human    64 CLEQGKEPWNVKRHEMVTEPPVVYSYFAQDLWPKQGKKNYFQKVILRTYKKCGRENLQLRKYCKS 128

  Fly    65 PD--KICEKCFKVL------------------------------------KMAFKFRETCQRSY- 90
            .|  |:.::|:..|                                    |.:||.:| |::|:
Human   129 MDECKVHKECYNGLNQCLTTTQNKIFQYDKYVKVFHKFSNSNRHKIGHTGKKSFKCKE-CEKSFC 192

  Fly    91 --GHLRQFVGPVEVEQRPPEKKGSETATKLEPDVDPDEAEQEPEHDEEDEDVDLDESHYAEADDA 153
              .||.|. ..:...::|.:.|....|.        :||.....|         ...|..:....
Human   193 MLSHLAQH-KRIHSGEKPYKCKECGKAY--------NEASNLSTH---------KRIHTGKKPYK 239

  Fly   154 AETQGGVFHDEIEDGILVELEKDRIVHV--KNEQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEM 216
            .|..|..|:.      |..|...:|:|.  |..:.||.|..........|::.....::.|..|.
Human   240 CEECGKAFNR------LSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEE 298

  Fly   217 ADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNP 281
            ..:|.|:.|              |.:||:     .:::.|:.:...:..:|...:...|..::
Human   299 CGRAFSQSS--------------TLTAHK-----IIHAGEKPYKCEECGKAFSQSSTLTTHKI-- 342

  Fly   282 RRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMS-IKSEKDISIGEV--------LAR 337
                     :.......|..:.|           .|.|::| :.:.|.|..||.        .|.
Human   343 ---------IHTGEKFYKCEECG-----------KAFSRLSHLTTHKRIHSGEKPYKCEECGKAF 387

  Fly   338 KHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQ 402
            |.|...|.  ||.:...:|.:|  |:||...:...|.||.|.::|:|.||::||.||..|..:.|
Human   388 KQSSTLTT--HKRIHAGEKFYK--CEVCSKAFSRFSHLTTHKRIHTGEKPYKCEECGKAFNLSSQ 448

  Fly   403 LARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHT 467
            |..|...|||.:||||..|..||...||.:||..|||.|:||:|:.|.|.|..::.|..||||||
Human   449 LTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTGEKPYKCEECGKAFNQSSHLTTHKMIHT 513

  Fly   468 GEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            ||||:.|:.|||.|..:..|..|::||
Human   514 GEKPYKCEECGKAFNNSSILNRHKMIH 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	24/135 (18%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	12/23 (52%)
		COG5048	386..>447	CDD:227381	30/60 (50%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	459..481	CDD:290200	15/21 (71%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630	6/8 (75%)
		KRAB	13..52	CDD:279668
		COG5048	179..563	CDD:227381	119/432 (28%)
		C2H2 Zn finger	184..204	CDD:275368	6/21 (29%)
		zf-H2C2_2	196..220	CDD:290200	6/32 (19%)
		C2H2 Zn finger	212..232	CDD:275368	5/36 (14%)
		zf-H2C2_2	224..249	CDD:290200	5/33 (15%)
		C2H2 Zn finger	240..260	CDD:275368	6/25 (24%)
		zf-H2C2_2	252..277	CDD:290200	7/24 (29%)
		C2H2 Zn finger	268..288	CDD:275368	4/19 (21%)
		zf-H2C2_2	280..305	CDD:290200	4/24 (17%)
		C2H2 Zn finger	296..316	CDD:275368	7/38 (18%)
		C2H2 Zn finger	324..344	CDD:275368	2/30 (7%)
		zf-H2C2_2	337..361	CDD:290200	4/45 (9%)
		zf-C2H2	350..372	CDD:278523	6/32 (19%)
		C2H2 Zn finger	352..372	CDD:275368	5/30 (17%)
		zf-H2C2_2	364..389	CDD:290200	5/24 (21%)
		C2H2 Zn finger	380..400	CDD:275368	6/21 (29%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		zf-H2C2_2	420..444	CDD:290200	11/23 (48%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		zf-H2C2_2	449..473	CDD:290200	12/23 (52%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		zf-H2C2_2	477..501	CDD:290200	12/23 (52%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		zf-H2C2_2	504..529	CDD:290200	16/24 (67%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910