DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF558

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_653294.1	Gene:	ZNF558 / 148156	HGNCID:	26422	Length:	402	Species:	Homo sapiens

Alignment Length:	185	Identity:	68/185 - (36%)
Similarity:	100/185 - (54%)	Gaps:	21/185 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 GIKTKGGHK-ILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLA 404
            |:||:..|: :.|.:       |:.|..::.::|.||:|.::|:|.||::|..||..|:....|.
Human   139 GVKTERSHRGVKLNE-------CNQCFKVFSTKSNLTQHKRIHTGEKPYDCSQCGKSFSSRSYLT 196

  Fly   405 RHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGE 469
            .|...|.|.:||:|::|..||:|.|:...|.||||.|:||||:.|...|..:..||.||.|||||
Human   197 IHKRIHNGEKPYECNHCGKAFSDPSSLRLHLRIHTGEKPYECNQCFHVFRTSCNLKSHKRIHTGE 261

  Fly   470 KPHVCDVCGKGFPQAYKLRNHRVIHERR--------GQSARESVAGLVSYDTANI 516
            ..|.|:.|||.|.....|..|..||...        |::.|:|     ||.|.::
Human   262 NHHECNQCGKAFSTRSSLTGHNSIHTGEKPYECHDCGKTFRKS-----SYLTQHV 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	27/60 (45%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	14/21 (67%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF558	NP_653294.1	KRAB	43..100	CDD:214630
		C2H2 Zn finger	154..174	CDD:275368	6/19 (32%)
		COG5048	<162..398	CDD:227381	61/155 (39%)
		C2H2 Zn finger	182..202	CDD:275368	6/19 (32%)
		C2H2 Zn finger	210..230	CDD:275368	8/19 (42%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		C2H2 Zn finger	266..286	CDD:275368	7/19 (37%)
		C2H2 Zn finger	294..314	CDD:275368	6/23 (26%)
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368
		C2H2 Zn finger	378..398	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000