Protein Alignment idc and ZNF578

DIOPT Version :10

• Sequence 1: NP_650862.1
• Gene: idc / 42393
• FlyBaseID: FBgn0038768
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001093164.1
• Gene: ZNF578 / 147660
• HGNCID: 26449
• Length: 590
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 113/429 - (26%)
• Similarity: 180/429 - (41%)
• Gaps: 76/429 - (17%)

  Fly   103 EQRPPEKKGSETATKL--------EPDVDPDEAEQE---PEHDEEDEDVDLDESHYAEADDAAET 156
            |:...::||.|....|        :..::...||.:   |.......:|.|:.....||.|.:..
Human     4 EEAAQKRKGKEPGMALPQGRLTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVDISSK 68

  Fly   157 ----------QGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLIPDQG 211
                      ||..  :.|..|:|...|.........:::|:|     ::|    :|.....|:.
Human    69 RMMKEVLSTGQGNT--EVIHTGMLQRHESYHTGDFCFQEIEKD-----IHD----FEFQSQKDER 122

  Fly   212 YDHEMADQALSELSAEIEYLDQVEH-------DQLTESAHEDDAEVDLNSTEEEFVPSKSVRASI 269
            ..||.:...:.||....:..|| .|       |||..|.|....|:.:...||:..
Human   123 NGHEASMPKIKELMGSTDRHDQ-RHAGNKPIKDQLGLSFHLHLPELHIFQPEEKIA--------- 177

  Fly   270 HARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSI-KSEKDISIGE 333
               |..::.||...|.:::..::....|....:.||..    .:|.....|..: ..||.....|
Human   178 ---NQVEKSVNDASSISTSQRISCRPETHTPNNYGNNF----FHSSLLTQKQEVHMREKSFQCNE 235

  Fly   334 V--------LARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHEC 390
            .        ..|||..|.        ||: |::|:  |:||.::..:..|..|.:.|:..||::|
Human   236 TGEAFNCSSFVRKHQIIH--------LGE-KQYKF--DICGKVFNEKRYLARHRRCHTSEKPYKC 289

  Fly   391 EICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTY 455
            ..||..|:....|..|...|||.:||||:.|..:|:..|:...|||.||.|:||:|:.|.|:|:|
Human   290 NECGKSFSYKSSLTCHRRCHTGEKPYKCNECGKSFSYKSSLTCHHRCHTGEKPYKCNECGKSFSY 354

  Fly   456 TNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            .::|:.|:.:|||.||:.|:.|||.|.|...|..|:.||
Human   355 KSSLRCHRRLHTGIKPYKCNECGKMFGQNSTLVIHKAIH 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
idc	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		COG5048	386..>447	CDD:227381	26/60 (43%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		SFP1	<424..491	CDD:227516	29/66 (44%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF578	NP_001093164.1	KRAB	24..60	CDD:460171	5/35 (14%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		COG5048	257..>582	CDD:227381	56/139 (40%)
		C2H2 Zn finger	262..281	CDD:275368	5/18 (28%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		C2H2 Zn finger	373..393	CDD:275368	8/19 (42%)
		C2H2 Zn finger	401..421	CDD:275368
		C2H2 Zn finger	429..449	CDD:275368
		C2H2 Zn finger	457..477	CDD:275368
		C2H2 Zn finger	485..505	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368