DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF480

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_653285.2	Gene:	ZNF480 / 147657	HGNCID:	23305	Length:	535	Species:	Homo sapiens

Alignment Length:	462	Identity:	126/462 - (27%)
Similarity:	177/462 - (38%)	Gaps:	142/462 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PDVDPD---EAEQEPEHDEEDEDVDLDE------------SHYAEADDAAE----TQGGV-FHDE 164
            ||::.:   |..:||...|.:..:..:.            |.||...:|.:    .|.|| ||..
Human    71 PDLNINSMLEQRREPWSGESEVKIAKNSDGRECIKGVNTGSSYALGSNAEDKPIKKQLGVSFHLH 135

  Fly   165 IEDGILVELEKD-RIVHVKNEQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELSAEI 228
            :.:   :||..| |:::..| |||                      ...:|..:...|.|:|:.:
Human   136 LSE---LELFPDERVINGCN-QVE----------------------NFINHSSSVSCLQEMSSSV 174

  Fly   229 E-------------YLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRV- 279
            :             :|.|.:...|.|..:|      .|...:.|..|.|:         ||.:|
Human   175 KTPIFNRNDFDDSSFLPQEQKVHLREKPYE------CNEHSKVFRVSSSL---------TKHQVI 224

  Fly   280 ----NPRRSATSTASVAVESSTSKTTDRGNPL-------------------KVRRGNSDSAGSKM 321
                .|.:.          :|..|...|.:.|                   ||...||:.|..:.
Human   225 HTVEKPYKC----------NSCGKVFSRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFARHQR 279

  Fly   322 SIKSEKDISIGE---------VLARKHSGIKT-----------KG-GHK--------ILLGDKKE 357
            ....||.....|         .||| |..|..           || .||        |..|:|
Human   280 IHTREKPYECNECGKVFSNNSYLAR-HQRIHAEEKPYKCNECGKGFSHKSSLANHWRIYTGEK-- 341

  Fly   358 FKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCP 422
             .|.||.||..:...:.|..|.|:|:|.||::|..||..|.|...||:|...|||.:||||:.|.
Human   342 -PYKCDECGKAFYRIALLVRHQKIHTGEKPYKCNECGKVFIQNSHLAQHWRIHTGEKPYKCNECG 405

  Fly   423 AAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKL 487
            ..|..||...:|.||||.|:||:|:.|.|.|:..:.|..|.:|||||||:.|..|||.|.....|
Human   406 KVFNQLSNLARHRRIHTGEKPYKCNECGKAFSEYSGLSAHLVIHTGEKPYKCSECGKAFRHKLSL 470

  Fly   488 RNHRVIH 494
            .||:.||
Human   471 TNHQRIH 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	29/60 (48%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF480	NP_653285.2	KRAB	27..87	CDD:214630	5/15 (33%)
		KRAB	27..66	CDD:279668
		COG5048	<158..501	CDD:227381	103/349 (30%)
		C2H2 Zn finger	205..225	CDD:275368	7/28 (25%)
		zf-H2C2_2	217..242	CDD:290200	7/43 (16%)
		C2H2 Zn finger	233..253	CDD:275368	4/29 (14%)
		zf-H2C2_2	245..270	CDD:290200	3/24 (13%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	4/24 (17%)
		C2H2 Zn finger	289..309	CDD:275368	5/20 (25%)
		zf-H2C2_2	301..326	CDD:290200	7/25 (28%)
		C2H2 Zn finger	317..336	CDD:275368	4/18 (22%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		zf-H2C2_2	358..382	CDD:290200	11/23 (48%)
		C2H2 Zn finger	373..393	CDD:275368	8/19 (42%)
		zf-H2C2_2	385..410	CDD:290200	12/24 (50%)
		zf-C2H2	399..421	CDD:278523	9/21 (43%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..437	CDD:290200	11/23 (48%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		zf-H2C2_2	442..466	CDD:290200	14/23 (61%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		zf-H2C2_2	469..494	CDD:290200	5/9 (56%)
		COG5048	481..>529	CDD:227381
		C2H2 Zn finger	485..505	CDD:275368
		zf-H2C2_2	497..522	CDD:290200
		C2H2 Zn finger	513..533	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000