DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZFP28

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_065879.1	Gene:	ZFP28 / 140612	HGNCID:	17801	Length:	868	Species:	Homo sapiens

Alignment Length:	314	Identity:	92/314 - (29%)
Similarity:	134/314 - (42%)	Gaps:	82/314 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 RNATKRRVNPRRSATSTASV--AVESSTSKTTDRGNPLKVR----RGNSDS---AGSKMSIKSE- 326
            |..|....:.:||...|..:  ..:|.....|||.:..|:.    |.|.||   .|.|:::..|
Human   291 RELTGSLFSGQRSVHETQELFPKQDSYAEGVTDRTSNTKLDCSSFRENWDSDYVFGRKLAVGQET 355

  Fly   327 ----KDISIGEVLARKHSGIKTKGGHKILLGD-----------------------------KKEF 358
                :.|:..:.|:::......|.|....|.|                             ||.|
Human   356 QFRQEPITHNKTLSKERERTYNKSGRWFYLDDSEEKVHNRDSIKNFQKSSVVIKQTGIYAGKKLF 420

  Fly   359 KYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKC----- 418
            |  |:.|...:...|.||.|.::|:|.||::|..||..|:.....|||...|||.:||:|
Human   421 K--CNECKKTFTQSSSLTVHQRIHTGEKPYKCNECGKAFSDGSSFARHQRCHTGKKPYECIECGK 483

  Fly   419 ------------SY------------CPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTL 459
                        .|            |..||:|....|:|.||||.|:||:||||||:|.|.::|
Human   484 AFIQNTSLIRHWRYYHTGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKPYKCDVCHKSFRYGSSL 548

  Fly   460 KFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH--------ERRGQSARESV 505
            ..|:.|||||||:.||||.|.|.....|..|:.:|        :..|::.|:::
Human   549 TVHQRIHTGEKPYECDVCRKAFSHHASLTQHQRVHSGEKPFKCKECGKAFRQNI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	29/89 (33%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/51 (24%)
		C2H2 Zn finger	418..438	CDD:275368	9/48 (19%)
		zf-H2C2_2	432..455	CDD:290200	16/22 (73%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		zf-H2C2_2	459..481	CDD:290200	14/21 (67%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	103..142	CDD:279668
		KRAB	232..288	CDD:214630
		KRAB	232..266	CDD:279668
		COG5048	417..806	CDD:227381	69/188 (37%)
		zf-C2H2	420..442	CDD:278523	8/23 (35%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..458	CDD:290200	10/23 (43%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	9/24 (38%)
		C2H2 Zn finger	478..496	CDD:275368	1/17 (6%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	16/23 (70%)
		C2H2 Zn finger	535..555	CDD:275368	10/19 (53%)
		zf-H2C2_2	547..572	CDD:290200	15/24 (63%)
		C2H2 Zn finger	563..583	CDD:275368	8/19 (42%)
		zf-H2C2_2	575..600	CDD:290200	4/24 (17%)
		C2H2 Zn finger	591..611	CDD:275368	2/12 (17%)
		zf-H2C2_2	603..627	CDD:290200	92/314 (29%)
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200
		C2H2 Zn finger	647..667	CDD:275368
		zf-H2C2_2	659..684	CDD:290200
		C2H2 Zn finger	675..695	CDD:275368
		zf-H2C2_2	687..710	CDD:290200
		C2H2 Zn finger	703..723	CDD:275368
		zf-H2C2_2	718..740	CDD:290200
		C2H2 Zn finger	731..751	CDD:275368
		zf-H2C2_2	743..768	CDD:290200
		C2H2 Zn finger	759..779	CDD:275368
		zf-H2C2_2	771..796	CDD:290200
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..835	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910