DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4936 and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	361	Identity:	107/361 - (29%)
Similarity:	150/361 - (41%)	Gaps:	68/361 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 IVHVKNEQVEE-----DGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEH- 236
            :.|....|:.|     |...::|......||.....|:...||.....:.:|:...|..|| .|
Human    68 VFHAGTLQIHESHHNGDFCYQDVDKDIHDYEFQWQEDERNGHEAPMTKIKKLTGITERYDQ-SHA 131

  Fly   237 ------DQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNPRRSATSTAS-VAVE 294
                  |||..|.|....|:.:..|||:.  ...|..|:|           ..|..|||. ::..
Human   132 RNKPIKDQLGSSFHSHLPEMHIFQTEEKI--DNQVVKSVH-----------DASLVSTAQRISCR 183

  Fly   295 SSTSKTTDRGNPLKVRRGNSDSAGSKMSI-KSEKDISIGEV-LARKHSGIKTKGGHKIL-LGDKK 356
            ..|..:.:.||..    .||.....|..: ..||.....|. .|..:|.:..|  |:|: |.|
Human   184 PKTHISNNHGNNF----WNSSLLTQKQEVHMREKSFQCNESGKAFNYSSLLRK--HQIIHLAD-- 240

  Fly   357 EFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYC 421
              ||.|||||.::..:..|..|.:.|:|..|::|..||..|:|...|..|...|||.:||||..|
Human   241 --KYKCDVCGKLFNQKRNLACHRRCHTGENPYKCNECGKTFSQTSSLTCHRRLHTGEKPYKCEEC 303

  Fly   422 PAA----------------------------FADLSTRNKHHRIHTNERPYECDVCHKTFTYTNT 458
            ..|                            |...|...:|||:||.|:||:|:.|.|||::.::
Human   304 DKAFHFKSILERHRIIHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNECGKTFSHKSS 368

  Fly   459 LKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            |..|..:||||||:.|:.|||.|.....|..||.:|
Human   369 LTCHHRLHTGEKPYKCNECGKTFSHKSSLTCHRRLH 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	9/23 (39%)
		COG5048	386..>447	CDD:227381	27/88 (31%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	11/50 (22%)
		C2H2 Zn finger	418..438	CDD:275368	8/47 (17%)
		zf-H2C2_2	432..455	CDD:290200	13/22 (59%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368	6/21 (29%)
		COG5048	242..617	CDD:227381	59/163 (36%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	3/19 (16%)
		C2H2 Zn finger	328..348	CDD:275368	5/19 (26%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
		C2H2 Zn finger	468..488	CDD:275368
		C2H2 Zn finger	496..516	CDD:275368
		C2H2 Zn finger	524..544	CDD:275368
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	580..600	CDD:275368
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	636..656	CDD:275368
		SFP1	<651..737	CDD:227516
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	692..712	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910