DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF275

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001354686.1	Gene:	ZNF275 / 10838	HGNCID:	13069	Length:	429	Species:	Homo sapiens

Alignment Length:	265	Identity:	79/265 - (29%)
Similarity:	115/265 - (43%)	Gaps:	56/265 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PSKSVRASIHARNATKRRVNP----------RRSATSTASVAVESSTSKTTDRGNPLKVRRGNSD 315
            ||:::..:...|...:|...|          :::|..:..:.|.|       |..|.     :.:
Human   160 PSRALENAAEKREQMEREAKPFECEECGKRFKKNAGLSQHLRVHS-------REKPF-----DCE 212

  Fly   316 SAGSKMSIK-----------SEKDISI----------GEVLARKHSGIKTKGGHKILLGDKKEFK 359
            ..|....:.           |||..:.          .|:|  ||..:.|  ||         ..
Human   213 ECGRSFKVNTHLFRHQKLHTSEKPFACKACSRDFLDRQELL--KHQRMHT--GH---------LP 264

  Fly   360 YICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAA 424
            :.||.||..:...:.|.||.::|||.||:.|..||..|.::.:|.:|...|||.:||.|..|..|
Human   265 FDCDDCGKSFRGVNGLAEHQRIHSGAKPYGCPHCGKLFRRSSELTKHRRIHTGEKPYACGQCGKA 329

  Fly   425 FADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRN 489
            |...|:..:|.|||:.||||.|..|.|.|...:.|..|:.||:|.||:.||.|||.|.::..|..
Human   330 FRQSSSLLEHARIHSGERPYACGECGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSR 394

  Fly   490 HRVIH 494
            ||.||
Human   395 HRRIH 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	12/23 (52%)
		COG5048	386..>447	CDD:227381	26/60 (43%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
ZNF275	NP_001354686.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..95
ZNF275	NP_001354686.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..176		3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910