Protein Alignment idc and ZNF234

DIOPT Version :10

• Sequence 1: NP_650862.1
• Gene: idc / 42393
• FlyBaseID: FBgn0038768
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_006621.1
• Gene: ZNF234 / 10780
• HGNCID: 13027
• Length: 700
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 140/549 - (25%)
• Similarity: 205/549 - (37%)
• Gaps: 119/549 - (21%)

  Fly    18 QKWIVCRVCLQQPKEPMASIFNDDSEKDL-----THMIRECG-------GVPIKQFDHYPDKI-- 68
            ||:..|    .:.|:....:||.|..:.|     :|...|||       .:.|.|..|..:|.
Human   145 QKFYQC----DEYKKSFTDVFNFDLHQQLHSGEKSHTCDECGKSFCYISALHIHQRVHMGEKCYK 205

  Fly    69 CEKCFKVLKMAFKFRETCQRSYGHLRQFVGPVEVEQRPPE--KKGSETAT-----KLEPDVDPDE 126
            |:.|.|         |..|.|:....|.|..||...:..|  |..|..:|     ||.....|..
Human   206 CDVCGK---------EFSQSSHLQTHQRVHTVEKPFKCVECGKGFSRRSTLTVHCKLHSGEKPYN 261

  Fly   127 AEQ------EPEHDEEDEDVDLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV--KN 183
            .|:      ...|.:|.:.:     |..|.....:|.|..|...      ..|....:||.  |.
Human   262 CEECGRAFIHASHLQEHQRI-----HTGEKPFKCDTCGKNFRRR------SALNNHCMVHTGEKP 315

  Fly   184 EQVEEDG----------IIEEVYDVYETYEGD------LIPDQGYDHEMADQALSELSAEIEYLD 232
            .:.|:.|          |.:.|:...:.|:.:      :.|.|...|....      :.|..|:.
Human   316 YKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECGKCFIQPSQFQAHRRIH------TGEKPYVC 374

  Fly   233 QV--------EHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNPRRSATSTA 289
            :|        ...|..:..|..:.....|..      .||.|..||.:.........:.......
Human   375 KVCGKGFIYSSSFQAHQGVHTGEKPYKCNEC------GKSFRMKIHYQVHLVVHTGEKPYKCEVC 433

  Fly   290 SVAVESST-----SKTTDRGNPLKVRR-GNSDSAGSKMSI--------KSEKDISIGEVLARK-- 338
            ..|...|:     .|......|.|... |...:..|::.|        |..|....|:..:|:
Human   434 GKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRAD 498

  Fly   339 ---HSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQA 400
               |..|.|        |:|   .|.|:.||.::...|.|..|.:||||.||.:||.||..|:::
Human   499 LKIHCRIHT--------GEK---PYNCEECGKVFSQASHLLTHQRVHSGEKPFKCEECGKSFSRS 552

  Fly   401 QQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMI 465
            ..|..|...|||.:||||..|...|......:.|.|:||.|:||.|..|.|.|:..::|:.|:.:
Human   553 AHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGECGKHFSQASSLQLHQSV 617

  Fly   466 HTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            ||||||:.||||||.|.::.:|:.||.:|
Human   618 HTGEKPYKCDVCGKVFSRSSQLQYHRRVH 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
idc	NP_650862.1	zf-AD	22..95	CDD:214871	20/86 (23%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		COG5048	386..>447	CDD:227381	25/60 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		SFP1	<424..491	CDD:227516	28/66 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	10/19 (53%)
ZNF234	NP_006621.1	KRAB	8..65	CDD:214630
		KRNB	91..147		1/1 (100%)
		COG5048	<101..306	CDD:227381	42/184 (23%)
		C2H2 Zn finger	150..170	CDD:275368	5/23 (22%)
		C2H2 Zn finger	178..198	CDD:275368	5/19 (26%)
		SUF4-like	202..>251	CDD:411020	15/57 (26%)
		C2H2 Zn finger	203..231	CDD:411020	10/36 (28%)
		C2H2 Zn finger	206..226	CDD:275368	7/28 (25%)
		C2H2 Zn finger	234..254	CDD:275368	5/19 (26%)
		C2H2 Zn finger	234..251	CDD:411020	4/16 (25%)
		COG5048	258..672	CDD:227381	108/423 (26%)
		C2H2 Zn finger	262..282	CDD:275368	3/24 (13%)
		C2H2 Zn finger	290..310	CDD:275368	4/25 (16%)
		C2H2 Zn finger	318..338	CDD:275368	3/19 (16%)
		C2H2 Zn finger	346..366	CDD:275368	3/19 (16%)
		C2H2 Zn finger	374..394	CDD:275368	2/19 (11%)
		C2H2 Zn finger	402..422	CDD:275368	6/25 (24%)
		C2H2 Zn finger	430..450	CDD:275368	3/19 (16%)
		C2H2 Zn finger	458..478	CDD:275368	3/19 (16%)
		C2H2 Zn finger	486..506	CDD:275368	3/19 (16%)
		C2H2 Zn finger	514..534	CDD:275368	6/19 (32%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	626..646	CDD:275368	10/19 (53%)
		C2H2 Zn finger	654..674	CDD:275368