DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and ZNF263

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_005732.2 Gene:ZNF263 / 10127 HGNCID:13056 Length:683 Species:Homo sapiens


Alignment Length:497 Identity:119/497 - (23%)
Similarity:184/497 - (37%) Gaps:147/497 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 ETCQRSYGHLRQFV----GPVEV---EQRPPEKKGSETATKLEP---DVDPDEAEQE-----PEH 133
            |..||..|.|||.|    ...||   |..|.|......:.||||   :..|....||     |:.
Human   117 EDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQR 181

  Fly   134 DEEDEDVDLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDV 198
            |.:                                           .||...:....:       
Human   182 DPQ-------------------------------------------AVKERALSAPWL------- 196

  Fly   199 YETYEGDLIPDQG--YDHEMADQALSELSAEIE-YLDQVEHDQLTESAHEDDAE--VDLNSTEEE 258
                  .|.|.:|  .|.||....|.|...::. |:.|      .|..|:|.::  :..::.:|.
Human   197 ------SLFPPEGNMEDKEMTGPQLPESLEDVAMYISQ------EEWGHQDPSKRALSRDTVQES 249

  Fly   259 FVPSKSVRASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDRG-NPLKVRRGNSDSAGSKMS 322
            :....|:.:.|.::.....:|.   ........:|:|.....:.|| .|.:.:..|.:...|..|
Human   250 YENVDSLESHIPSQEVPGTQVG---QGGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCS 311

  Fly   323 IKSEKDISI-----GEV-----LARKHSGIK------TKGGHKIL---------LGDKKEFK--- 359
            ......:.:     |||     |.|.|...:      .:||.:..         ||..||.:   
Human   312 ENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWAPPPEGGMEQALAGASSGRELGRPKELQPKK 376

  Fly   360 -YICDVCGNMYPSQSRLTEHIKVHS----------------------------GVKPHECEICGH 395
             ::|.:||..:.:.|.|..|.::|:                            |.:.|:|..||.
Human   377 LHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGK 441

  Fly   396 CFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLK 460
            ||:|...|.||..||||.:||:|:.|...|:..|..::|.|.||.|:||:|..|.:.|.:::.|.
Human   442 CFSQNTHLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLL 506

  Fly   461 FHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHERRGQSAR 502
            .|:.|||||:|:.|..|||.|.::    :|.|||||..:..|
Human   507 RHQRIHTGERPYKCPECGKSFSRS----SHLVIHERTHERER 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871 5/10 (50%)
C2H2 Zn finger 362..382 CDD:275368 6/19 (32%)
zf-H2C2_2 375..399 CDD:290200 10/51 (20%)
COG5048 386..>447 CDD:227381 27/60 (45%)
C2H2 Zn finger 390..410 CDD:275368 9/19 (47%)
zf-H2C2_2 403..426 CDD:290200 11/22 (50%)
C2H2 Zn finger 418..438 CDD:275368 6/19 (32%)
zf-H2C2_2 432..455 CDD:290200 10/22 (45%)
C2H2 Zn finger 446..466 CDD:275368 5/19 (26%)
zf-H2C2_2 459..481 CDD:290200 12/21 (57%)
C2H2 Zn finger 474..494 CDD:275368 7/19 (37%)
ZNF263NP_005732.2 SCAN 38..149 CDD:128708 12/31 (39%)
Dendrin <128..>347 CDD:317849 49/283 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..185 10/80 (13%)
KRAB 218..277 CDD:214630 9/67 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..301 12/73 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..368 9/45 (20%)
C2H2 Zn finger 380..400 CDD:275368 6/19 (32%)
zf-C2H2 380..400 CDD:306579 6/19 (32%)
COG5048 <434..649 CDD:227381 50/115 (43%)
C2H2 Zn finger 436..456 CDD:275368 9/19 (47%)
C2H2 Zn finger 464..484 CDD:275368 6/19 (32%)
C2H2 Zn finger 492..512 CDD:275368 5/19 (26%)
C2H2 Zn finger 520..540 CDD:275368 11/23 (48%)
C2H2 Zn finger 577..597 CDD:275368
C2H2 Zn finger 605..625 CDD:275368
COG5048 629..>682 CDD:227381
C2H2 Zn finger 633..653 CDD:275368
C2H2 Zn finger 661..681 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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