DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF730

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_016881603.1	Gene:	ZNF730 / 100129543	HGNCID:	32470	Length:	514	Species:	Homo sapiens

Alignment Length:	317	Identity:	95/317 - (29%)
Similarity:	139/317 - (43%)	Gaps:	65/317 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 DLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASI 269
            ||.|:||..               :|..:|...|..:..||:..........:||        .:
Human    95 DLWPEQGIK---------------DYFQEVILRQYKKCRHENLLLRKGCKNVDEF--------KM 136

  Fly   270 HARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSIKSEKDISIGE- 333
            |     |:..|......:|       |.||.......:||....|:|...|:...|:|.....|
Human   137 H-----KKGYNRHNQCLTT-------SHSKIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKCKEC 189

  Fly   334 -----VLA------RKHSGIKT----KGG-----------HKILLGDKKEFKYICDVCGNMYPSQ 372
                 :|:      :.|:|.|:    :.|           || .:.:||.:|  |..||..:...
Human   190 GKLFCILSHLAQHKKIHTGEKSYKCEEYGKAFNESSNCTTHK-RITEKKPYK--CKECGKAFNWF 251

  Fly   373 SRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRI 437
            |..|.|.::|:|.||::||.||..|.|:..|..|...|||.:||||..|..||...|...:|.:|
Human   252 SHFTTHKRIHTGEKPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKI 316

  Fly   438 HTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            ||.|:||:|:.|.|.|.:::||..||.||.||||:.|:.|||.|.::..|..|::.|
Human   317 HTKEQPYKCEKCGKAFKWSSTLTKHKRIHNGEKPYKCEECGKAFNRSSTLNRHKITH 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF730	XP_016881603.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000