DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF845

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	200	Identity:	70/200 - (35%)
Similarity:	98/200 - (49%)	Gaps:	27/200 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 THAKPEKCDRSGR-----KPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTE 289
            |..|..||:..|:     ..:.||:        :...|.||      |.|:.|...:..::.|..
Human   322 TGEKSYKCNECGKTFSQTSYLVYHR--------RLHTGEKP------YKCEECDKAFSFKSNLER 372

  Fly   290 HMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKER 354
            |.|.|:|.||::|..|.|.|.:...|.||...|||.:|||||.|...|:..|:...|.|:||.|:
Human   373 HRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTFSQMSSLVYHRRLHTGEK 437

  Fly   355 PYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEES 419
            ||.|:.|...|::..||:.|:.|||||||:.|:.|||.|.:...|..||..|.        .|:.
Human   438 PYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHT--------GEKP 494

  Fly   420 TKAED 424
            .|.|:
Human   495 YKCEE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	59/146 (40%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		zf-H2C2_2	315..338	CDD:290200	12/22 (55%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	14/23 (61%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	70/199 (35%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368	4/27 (15%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		COG5048	381..813	CDD:227381	52/126 (41%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	453..478	CDD:290200	15/24 (63%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	1/2 (50%)
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	525..545	CDD:275368
		zf-H2C2_2	537..560	CDD:290200
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		zf-H2C2_2	649..674	CDD:290200
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		zf-H2C2_2	761..786	CDD:290200
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000