DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trem and ZNF468

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:XP_016882932.1 Gene:ZNF468 / 90333 HGNCID:33105 Length:541 Species:Homo sapiens


Alignment Length:218 Identity:71/218 - (32%)
Similarity:104/218 - (47%) Gaps:18/218 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 THAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFH 294
            |..||.||:..|:   .:..||..........|.||      |.|:.|..::..::.|..|.:.|
Human   285 TGEKPYKCNECGK---TFGHNSSLFIHKALHTGEKP------YECEECDKVFSRKSHLERHKRIH 340

  Fly   295 SGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCD 359
            :|.||::|::|...|..|..|.:|...|||.:||.||.|...|...||..:|||:||.|:||.|:
Human   341 TGEKPYKCKVCDEAFAYNSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARHHRLHTGEKPYKCE 405

  Fly   360 VCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWR---------ND 415
            .|.:.|:...:|:.|:.||:||||:.|:.|.|.|.:...|..||..|.....::         .|
Human   406 ECDKVFSRKSHLERHRRIHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKPYKCKVCDKAFQRD 470

  Fly   416 AEESTKAEDVKGETPEFLNELPK 438
            :..:.......||.|...||..|
Human   471 SHLAQHQRVHTGEKPYKCNECGK 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 55/146 (38%)
C2H2 Zn finger 274..294 CDD:275368 4/19 (21%)
zf-H2C2_2 287..311 CDD:290200 9/23 (39%)
C2H2 Zn finger 302..322 CDD:275368 6/19 (32%)
zf-H2C2_2 315..338 CDD:290200 10/22 (45%)
C2H2 Zn finger 330..350 CDD:275368 9/19 (47%)
zf-H2C2_2 345..367 CDD:290200 11/21 (52%)
C2H2 Zn finger 358..378 CDD:275368 5/19 (26%)
zf-H2C2_2 370..394 CDD:290200 11/23 (48%)
C2H2 Zn finger 386..406 CDD:275368 7/19 (37%)
ZNF468XP_016882932.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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