DRSC/TRiP Functional Genomics Resources

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Protein Alignment trem and ZNF408

DIOPT Version :10

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_079017.1 Gene:ZNF408 / 79797 HGNCID:20041 Length:720 Species:Homo sapiens


Alignment Length:422 Identity:106/422 - (25%)
Similarity:153/422 - (36%) Gaps:135/422 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LDREASNA-----NAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGMKVEG---------EED- 138
            ||:||:.|     .:|.:.::.|..||.:...:     |..||...|::.|.         .:| 
Human   185 LDKEAAVAVVTEVESAVQQEVASPGEDAAEPCI-----DPGSQSPSGIQAENMVSPGLKFPTQDR 244

  Fly   139 --QQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGS 201
              :..|.:..:::|||.|                  ||....|:... ||.:|..:.:.....|:
Human   245 ISKDSQPLGPLLQDGDVD------------------EECPAQAQMPP-ELQSNSATQQDPDGSGA 290

  Fly   202 TGTDVATEEPPEEEIAEDILDSDEDYDPTHAK-PEK-CDRSG-----RKPVAYHKNSPK------ 253
            :.:..|....|...:|:. |.|..|..|..|| ||. ..:||     |.|.....:|||      
Human   291 SFSSSARGTQPHGYLAKK-LHSPSDQCPPRAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGRRYR 354

  Fly   254 --------------------------------------VETFKKKV----GRKPRNKLSTYICDV 276
                                                  .|:||..:    |.:|      :.|..
Human   355 CGECGKAFLQLCHLKKHAFVHTGHKPFLCTECGKSYSSEESFKAHMLGHRGVRP------FPCPQ 413

  Fly   277 CGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQ------------------------------ 311
            |...|.||..|.||...|||.:|..|:.||:.|.:                              
Human   414 CDKAYGTQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRLHRKTHQVPAAPAPCPCPVCGRPLA 478

  Fly   312 NQQLVR-HMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHK 375
            ||..:| ||..|||.:|:.|.:|..||..|.....|.|:||.||||.|..|:..|.....|:.|.
Human   479 NQGSLRNHMRLHTGEKPFLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCADAFPQLPELRRHL 543

  Fly   376 MIHTGEKPHVCDLCGKGFVKAYKLRLHRETHN 407
            :.|||| .|:|.:|||.....:.||.|...|:
Human   544 ISHTGE-AHLCPVCGKALRDPHTLRAHERLHS 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 57/175 (33%)
C2H2 Zn finger 274..294 CDD:275368 8/19 (42%)
C2H2 Zn finger 302..322 CDD:275368 9/50 (18%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
C2H2 Zn finger 358..378 CDD:275368 5/19 (26%)
C2H2 Zn finger 386..406 CDD:275368 7/19 (37%)
ZNF408NP_079017.1 PR-SET_PRDM17 53..176 CDD:380918
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..350 39/173 (23%)
COG5048 <308..516 CDD:227381 51/214 (24%)
C2H2 Zn finger 355..375 CDD:275368 0/19 (0%)
C2H2 Zn finger 383..403 CDD:275368 3/19 (16%)
C2H2 Zn finger 411..431 CDD:275368 8/19 (42%)
C2H2 Zn finger 439..490 CDD:275368 9/50 (18%)
COG5048 <475..642 CDD:227381 40/101 (40%)
zf-H2C2_2 482..507 CDD:463886 11/24 (46%)
C2H2 Zn finger 498..518 CDD:275368 7/19 (37%)
C2H2 Zn finger 526..546 CDD:275368 5/19 (26%)
C2H2 Zn finger 553..573 CDD:275368 7/19 (37%)
C2H2 Zn finger 581..601 CDD:275368
C2H2 Zn finger 609..629 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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