Protein Alignment trem and ZNF205

DIOPT Version :10

• Sequence 1: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_003447.2
• Gene: ZNF205 / 7755
• HGNCID: 12996
• Length: 554
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 91/299 - (30%)
• Similarity: 139/299 - (46%)
• Gaps: 38/299 - (12%)

  Fly   120 WEDYA---SQLDGGMKVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEY 181
            |...|   .:..|..:..|:|.:.....|..||.|....|:........:|.       .|.|..
Human   170 WAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPF-------RTRAGR 227

  Fly   182 EEYELLTNENSPEIAQEKG---STGTDVATEEPPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRK 243
            .::.:      |:.|||..   |:|....:.:|.|.:...|....    ||:..:|::. |...|
Human   228 VQWGV------PQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPP----DPSPTEPQEY-RVPEK 281

  Fly   244 PVAYHKNSPKVETFKK------KVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHEC 302
            |....|.:|  |:.::      :||||      :|.|:.||..:...:.|..|.:.|:|.||:.|
Human   282 PNEEEKGAP--ESGEEGLAPDSEVGRK------SYRCEQCGKGFSWHSHLVTHRRTHTGEKPYAC 338

  Fly   303 EICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTY 367
            ..||:.|.::..|::|...|||.:||.|..|..:|:..||..:|.||||.|:|||||.|::.||.
Human   339 TDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTR 403

  Fly   368 SDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH 406
            ..:|..|:..|||.|||.|.:|.|.|.::..|..|:.||
Human   404 RSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTH 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	57/143 (40%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
ZNF205	NP_003447.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74
		KRAB	124..>168	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..195		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..303		14/69 (20%)
		COG5048	<306..486	CDD:227381	57/143 (40%)
		C2H2 Zn finger	310..330	CDD:275368	5/19 (26%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		C2H2 Zn finger	450..470	CDD:275368
		zf-C2H2	476..498	CDD:395048
		C2H2 Zn finger	478..498	CDD:275368
		zf-C2H2	504..526	CDD:395048
		C2H2 Zn finger	506..526	CDD:275368