DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and Zfp735

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001119961.1	Gene:	Zfp735 / 76390	MGIID:	1923640	Length:	734	Species:	Mus musculus

Alignment Length:	179	Identity:	66/179 - (36%)
Similarity:	100/179 - (55%)	Gaps:	11/179 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 THAKPEKCDRSGRKPVAYHKNSPKVETFKK-KVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKF 293
            |..||.||::.|:    |...|..::..:: ..|.||      |.|:.||..:...:.|..|.:.
Mouse   562 TGDKPYKCNKCGK----YFTRSSNLQVHQRVHTGDKP------YECNKCGKSFTQSSSLKIHHRI 616

  Fly   294 HSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVC 358
            |:|.||:.|..||:.|:::..|..|...|||::|||||.|..:|...|:...||:|||.::||.|
Mouse   617 HTGDKPYRCNECGKCFIRSSNLKVHQRVHTGDKPYKCNECGKSFTQSSSLKVHHKIHTGDKPYKC 681

  Fly   359 DVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHN 407
            :.|.::|..|.:||.|..||||:||:.|:.|||.|.:...|:.|...|:
Mouse   682 NECGKSFIQSSDLKNHYRIHTGDKPYKCNECGKSFRQCSDLKNHYRIHS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	57/144 (40%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	13/23 (57%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
Zfp735	NP_001119961.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	485..505	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368
		COG5048	<529..725	CDD:227381	64/172 (37%)
		C2H2 Zn finger	542..561	CDD:275368
		zf-H2C2_2	553..578	CDD:290200	7/19 (37%)
		C2H2 Zn finger	569..589	CDD:275368	4/23 (17%)
		zf-H2C2_2	581..606	CDD:290200	7/30 (23%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		zf-H2C2_2	609..634	CDD:290200	10/24 (42%)
		zf-C2H2	623..645	CDD:278523	6/21 (29%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		zf-H2C2_2	637..662	CDD:290200	12/24 (50%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		zf-H2C2_2	665..690	CDD:290200	10/24 (42%)
		C2H2 Zn finger	681..701	CDD:275368	7/19 (37%)
		zf-H2C2_2	693..718	CDD:290200	14/24 (58%)
		C2H2 Zn finger	709..729	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050