Protein Alignment trem and Zfp444

DIOPT Version :10

• Sequence 1: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_082592.2
• Gene: Zfp444 / 72667
• MGIID: 1923365
• Length: 331
• Species: Mus musculus
• Alignment Length: 396
• Identity: 87/396 - (21%)
• Similarity: 133/396 - (33%)
• Gaps: 141/396 - (35%)

  Fly    57 PDKMCSKCVRCLRL---CYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLK 118
            |.|..:..|..|.|   .::||      |.|:.|          |||..:.|.:     :.::.:
Mouse     8 PVKQENLAVEALTLDSPWHRFR------HFHLGD----------AAGPREALGL-----LRALCR 51

  Fly   119 SW-----------------EDYASQLDGGMKVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDP-T 165
            .|                 |.:.|.|..        |.|..|.:...:.|:.....:.::..| |
Mouse    52 DWLQPEVHTKEQMLELLVLEQFLSALPA--------DTQAWVCSRRPQSGEEAVALLEELWGPAT 108

  Fly   166 QP-------VPNEIEEAETYAEYEEYELLTNENSPEIA---QEKGS--TGTDVATEEPPEEEIAE 218
            .|       .|.::.|                 .|.::   :|.|:  .||...||.|..|
Mouse   109 SPDGSSAMRAPRDVTE-----------------GPGVSVGKEESGAIPLGTSSGTEVPATE---- 152

  Fly   219 DILDSDEDYDPTHAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLS-----------TY 272
                                           ||..:..:|::.|..|...|:           |.
Mouse   153 -------------------------------NSGAMRPYKQEPGSPPPAPLAPVLPAFLAAPGTV 186

  Fly   273 ICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAF 337
            .|..||......|.|..|.:.|||.|||.|..||:.|.:.:.|.||..||.|:........||
Mouse   187 SCPECGKSPLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRGTHPGSPGPALRPLPA-- 249

  Fly   338 ADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLH 402
                          :|:|:.|..|.:||.:.::|..|:..|:|.:|..|..|||||.:...:..|
Mouse   250 --------------REKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRH 300

  Fly   403 RETHNR 408
            :..|.|
Mouse   301 QRIHGR 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	9/32 (28%)
		COG5048	<264..411	CDD:227381	47/156 (30%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	2/19 (11%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
Zfp444	NP_082592.2	SCAN	26..103	CDD:460417	17/105 (16%)
		COG5048	<186..>284	CDD:227381	35/113 (31%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-C2H2	282..304	CDD:395048	7/21 (33%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)