DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and CG18764

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	106/439 - (24%)
Similarity:	173/439 - (39%)	Gaps:	102/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRVC---LNNPS-------EGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVR 66
            ||.|   :.|..       |.|::|.||...|.:|     ||        .|...|..:|:.|..
  Fly     5 CRTCGSIIYNKMPKNLFHIENEKMLQDINLVTGTT-----LH--------NDPELPSSICACCTL 56

  Fly    67 CLRLCYKFRLTCQRSHQHIMDMLDREASNANAAGEG--------DLLS---------IAE----- 109
            .|.....||..|..:.:.::..  |.:..|....|.        |.|:         |.|
  Fly    57 DLNQAILFRERCILTQKQLVHR--RRSPEAKEPAEDVEEMASPPDCLNDPFGEVDEYIVESPEEV 119

  Fly   110 ---------DLSVESVLKSWEDYASQLDGGMKVEGEEDQQ--HQVITYVVEDGDT---DDTNMFD 160
                     ||..::.:.|.||..:..|  |....|||.|  ..:|:.|.::.::   ||:|. |
  Fly   120 LDHDSDAHHDLDEDNYIDSVEDVDALQD--MAEVAEEDSQDVESLISSVQKELESICNDDSNS-D 181

  Fly   161 VHDPTQPVPNEIEEAETYAE-YEEYELLTNENSPEIAQEKGSTGTDVATEEPPEEEIAEDILDSD 224
            .:|..:|     :....:.| ..|||:.:|.|:| :.:.|.:.|...
  Fly   182 NNDYMEP-----QNGSYFNETINEYEVSSNPNTP-LPESKSAAGRST------------------ 222

  Fly   225 EDYDPTHAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTE 289
               .|...||::     :|.....||..:.:..::|..::.|.    .:|:.||..:..|:....
  Fly   223 ---KPATTKPKR-----KKQYVTWKNMTEEQIIERKRLQRKRE----CVCEQCGRQFTDQSNFKL 275

  Fly   290 HMKFHSGVKPHECEICGRGFVQNQQLVRHMN-THTGNRPYKCNYCPAAFADRSTKTKHHRIHTKE 353
            ||..|:|.|...|:.||:.|..:..:..|.. .|.|.:||.|.:|..:|.:.:|:..|.|.||..
  Fly   276 HMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNA 340

  Fly   354 RPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLH 402
            :||.|..|.:.|..:...|.|::||||.:...|.:|.:.|.:...|:.|
  Fly   341 KPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAH 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	21/84 (25%)
		COG5048	<264..411	CDD:227381	43/140 (31%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	5/20 (25%)
		zf-H2C2_2	315..338	CDD:290200	7/23 (30%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	345..367	CDD:290200	9/21 (43%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..394	CDD:290200	8/23 (35%)
		C2H2 Zn finger	386..406	CDD:275368	5/17 (29%)
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	21/82 (26%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..309	CDD:275368	5/20 (25%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960