Protein Alignment trem and RBAK

DIOPT Version :10

• Sequence 1: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_066986.1
• Gene: RBAK / 57786
• HGNCID: 17680
• Length: 714
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 124/502 - (24%)
• Similarity: 186/502 - (37%)
• Gaps: 159/502 - (31%)

  Fly     2 KTESNEKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVR 66
            :..:.||...|.||      |:.     ||:..:..:.:..|:         :..|.| |::|.:
Human   281 RAHTGEKPYECNVC------GKS-----FSQKGTLTVHRRSHL---------EEKPYK-CNECGK 324

  Fly    67 CLRLCYKFRLT---------------------CQRSHQHIMDMLDREASN-----ANAAGEGDLL 105
              ..|.|..||                     ||::|   :.:..|..|.     .|..|
Human   325 --TFCQKLHLTQHLRTHSGEKPYECSECGKTFCQKTH---LTLHQRNHSGERPYPCNECG----- 379

  Fly   106 SIAEDLSVESVL-------------------KSWEDYASQLDGGMKVEGEEDQQ-------HQVI 144
               :..|.:|.|                   ||:...::.:.......||:..|       ...:
Human   380 ---KSFSRKSALSDHQRTHTGEKLYKCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRV 441

  Fly   145 TYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGSTGTDVATE 209
            :|:.            :|     ..:.:|| :.| |..|.....|.||..|...|      |.||
Human   442 SYLT------------IH-----YRSHLEE-KPY-ECNECGKTFNLNSAFIRHRK------VHTE 481

  Fly   210 EPPEE-----EIAEDILDSDEDYDPTH--AKPEKCDRSGRKPVAY-----HKNSPKVETFKKKVG 262
            |...|     :.::..|   .|:...|  .||.:|:..|:..:..     |:..||.|
Human   482 EKSHECSECGKFSQLYL---TDHHTAHLEEKPYECNECGKTFLVNSAFDGHQPLPKGE------- 536

  Fly   263 RKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRP 327
                   .:|.|:|||.::...:..|||.:.||..||:.|..||:.|..|..|.||...|||.:|
Human   537 -------KSYECNVCGKLFNELSYYTEHYRSHSEEKPYGCSECGKTFSHNSSLFRHQRVHTGEKP 594

  Fly   328 YKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKG 392
            |:|..|...|:.:|..|.|||||:.|:||.|..|.:.|:...||..|...|:||||:.|:.|||.
Human   595 YECYECGKFFSQKSYLTIHHRIHSGEKPYECSKCGKVFSRMSNLTVHYRSHSGEKPYECNECGKV 659

  Fly   393 FVKAYKLRLHRETHNRRITWRNDAEESTKAEDVKGETPEFLNELPKE 439
            |.:...|.:|..||:                   ||.|...||..|:
Human   660 FSQKSYLTVHYRTHS-------------------GEKPYECNECGKK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	18/96 (19%)
		COG5048	<264..411	CDD:227381	58/146 (40%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
RBAK	NP_066986.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	165..199	CDD:275368
		Required for interaction with RB1. /evidence=ECO:0000269|PubMed:10702291	171..260
		C2H2 Zn finger	207..227	CDD:275368
		SUF4-like	259..>307	CDD:411020	8/36 (22%)
		C2H2 Zn finger	263..284	CDD:411020	0/2 (0%)
		C2H2 Zn finger	263..283	CDD:275368	0/1 (0%)
		C2H2 Zn finger	291..311	CDD:275368	6/30 (20%)
		zf-C2H2	317..339	CDD:395048	7/24 (29%)
		C2H2 Zn finger	319..339	CDD:275368	6/21 (29%)
		COG5048	343..701	CDD:227381	107/417 (26%)
		C2H2 Zn finger	347..367	CDD:275368	4/22 (18%)
		C2H2 Zn finger	375..395	CDD:275368	5/27 (19%)
		C2H2 Zn finger	403..423	CDD:275368	2/19 (11%)
		Interaction with AR. /evidence=ECO:0000269|PubMed:14664718	417..714		95/332 (29%)
		C2H2 Zn finger	431..451	CDD:275368	2/36 (6%)
		C2H2 Zn finger	459..479	CDD:275368	6/25 (24%)
		C2H2 Zn finger	513..533	CDD:275368	3/19 (16%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		C2H2 Zn finger	597..617	CDD:275368	8/19 (42%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		C2H2 Zn finger	681..701	CDD:275368	3/7 (43%)