DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF492

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_065906.1	Gene:	ZNF492 / 57615	HGNCID:	23707	Length:	531	Species:	Homo sapiens

Alignment Length:	191	Identity:	76/191 - (39%)
Similarity:	104/191 - (54%)	Gaps:	13/191 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 KPEKCDRSGRKPVAYHKNSPKVETFKK-KVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSG 296
            ||.||...|:   ||::.| .:.|.|: ..|:||      |.|:.||..:...:.||.|...|:|
Human   167 KPYKCKECGK---AYNETS-NLSTHKRIHTGKKP------YKCEECGKAFNRLSHLTTHKIIHTG 221

  Fly   297 VKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVC 361
            .||::||.||:.|.|:..|..|...|||.:||||..|..||:..||.|.|..||..|:||.|:.|
Human   222 KKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKIIHAGEKPYKCEEC 286

  Fly   362 SRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKA 422
            .:.|:.|..|..||:||||||.:.|:.|||.|.:...|..|:..|:....::  .||..||
Human   287 GKAFSQSSTLTTHKIIHTGEKFYKCEECGKAFSQLSHLTTHKRIHSGEKPYK--CEECGKA 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	61/146 (42%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..367	CDD:290200	9/21 (43%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	13/23 (57%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
ZNF492	NP_065906.1	KRAB	<1..32	CDD:214630
		COG5048	138..522	CDD:227381	76/191 (40%)
		C2H2 Zn finger	143..163	CDD:275368
		zf-H2C2_2	155..179	CDD:290200	6/14 (43%)
		C2H2 Zn finger	171..191	CDD:275368	7/23 (30%)
		zf-H2C2_2	183..208	CDD:290200	9/30 (30%)
		C2H2 Zn finger	199..219	CDD:275368	6/19 (32%)
		zf-H2C2_2	211..236	CDD:290200	12/24 (50%)
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	8/19 (42%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..348	CDD:290200	7/25 (28%)
		C2H2 Zn finger	339..359	CDD:275368	4/7 (57%)
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		zf-H2C2_2	408..432	CDD:290200
		C2H2 Zn finger	423..443	CDD:275368
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..488	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910