DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and CG4424

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	124/423 - (29%)
Similarity:	179/423 - (42%)	Gaps:	124/423 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VCRVCLNNPSEGEELLHDIFSETASTRLDQMLHIC------AGIPV---SLDDNFPDKMCSKCVR 66
            :||.||   .:||..:..|| :||..||...:.:|      :||.:   :.::..|.::|.:|..
  Fly    10 LCRTCL---QDGEAHMVSIF-QTADDRLPGGVSLCDKIESLSGIQIRATAKEEVLPTRICLRCKA 70

  Fly    67 CLRLCYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGM 131
            .|.|.:|||..||||::.:.:
  Fly    71 FLTLAHKFRQICQRSNEFLRE-------------------------------------------- 91

  Fly   132 KVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIA 196
                          ||::|.            ..|.|..|:                      :.
  Fly    92 --------------YVIKDA------------VEQGVVKEV----------------------VQ 108

  Fly   197 QEKGSTGTDVATE--EPPEEEIAEDILDSDED--YDPTHAKPEKCDRS-----GRKPVAYHKNSP 252
            |.:.||...:.||  ||||:|:.|:.:.|.||  .:..|...|| :|.     ...|..|   .|
  Fly   109 QTRPSTPPPIETEQLEPPEDEVLEEGVWSTEDPIEETPHGPAEK-ERPTVLTVEMLPAPY---PP 169

  Fly   253 KVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVR 317
            ...|.........:.||  ::|.:|||.||.::.|..||:.|:..:|:|||||.:.|..|.||.|
  Fly   170 PASTPPPAPAGAVKGKL--HVCAICGNGYPRKSTLDTHMRRHNDERPYECEICHKSFHVNYQLKR 232

  Fly   318 HMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEK 382
            |:..|||.:||.|.||...||||::..||.|.|..||||.|..|.:.|||:..||.|...|||||
  Fly   233 HIRQHTGAKPYTCQYCQRNFADRTSLVKHERTHRNERPYACKTCGKKFTYASVLKMHYKTHTGEK 297

  Fly   383 PHVCDLCGKGFVKAYKLRLHRET----HNRRIT 411
            ||:|.||.|.|.:.:.|..|.:|    ::.|:|
  Fly   298 PHICQLCNKSFARIHNLVAHLQTQQHINDPRLT 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	27/84 (32%)
		COG5048	<264..411	CDD:227381	68/150 (45%)
		C2H2 Zn finger	274..294	CDD:275368	9/19 (47%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	10/19 (53%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	10/19 (53%)
		zf-H2C2_2	345..367	CDD:290200	11/21 (52%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..394	CDD:290200	14/23 (61%)
		C2H2 Zn finger	386..406	CDD:275368	8/23 (35%)
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	27/143 (19%)
		C2H2 Zn finger	189..209	CDD:275368	9/19 (47%)
		DUF45	<204..281	CDD:302795	37/76 (49%)
		COG5048	210..>345	CDD:227381	57/121 (47%)
		C2H2 Zn finger	217..237	CDD:275368	10/19 (53%)
		C2H2 Zn finger	245..265	CDD:275368	10/19 (53%)
		zf-H2C2_2	257..282	CDD:290200	11/24 (46%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	15/23 (65%)
		C2H2 Zn finger	301..320	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C1GA
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.790