DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and CG17801

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_650660.2	Gene:	CG17801 / 42144	FlyBaseID:	FBgn0038550	Length:	381	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	107/438 - (24%)
Similarity:	171/438 - (39%)	Gaps:	98/438 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRVCLN-----NPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVRCLRLC 71
            |.:|.:     ||:       .||......::..:    .||.:..::..|..:|..|:..|...
  Fly    10 CHLCASCFCHLNPT-------IIFCLEVLAKIKDL----TGIWLEQNERQPRHICPSCLNDLNTS 63

  Fly    72 YKFRLTCQRSHQHIMDMLDREASNANAAG-EGDLLSIAEDLSVE---SVLKSWEDYASQLDGGMK 132
            .|.:...||.|        .||:....:| :.||.|...|:..|   |.|:|.|.|
  Fly    64 IKLKKRIQRVH--------NEATLRRESGLDEDLESTVSDIEPEGDSSDLESEESY--------- 111

  Fly   133 VEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYE------EYELLTNEN 191
                 |.::.......|:.|. |.|:  .|:..:..|:...::||...::      |.....|||
  Fly   112 -----DSENYPFDKKAEESDI-DLNL--AHEDRRNEPHNPYDSETPLIFKHKNPLIETPSFANEN 168

  Fly   192 SPEIAQEKG-------STGTDV-ATEEPPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYH 248
            .|.....|.       ..|||: .....|..::.:.:..:.||....:..|.|  |:.|
  Fly   169 LPNKVDAKSPKKGNFIQIGTDLRLLTTYPSIKVVKPLALAPEDVAAENVPPAK--RTAR------ 225

  Fly   249 KNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQN- 312
                               |:.:.:|..||.::.|...|..||..|:|.|...|..|.:.||..
  Fly   226 -------------------KMQSLVCPKCGRVFKTPYNLKTHMVRHTGEKNFPCTFCDKRFVTKY 271

  Fly   313 ----QQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRI-HTKERPYVCDVCSRTFTYSDNLK 372
                .:.||||    |.:|::||:|.|.|...:.|:.|.|| |.::..|.||.|::.|.....|.
  Fly   272 LARLHERVRHM----GEQPFECNFCSATFFTSTAKSSHERIRHIRDLRYQCDQCTKRFNTKTCLN 332

  Fly   373 FHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRET--HNRRITWRNDAEE 418
            .||.:|:|.||..|.:|...|.:...||.|.::  |.:|.:...::||
  Fly   333 KHKFLHSGLKPFDCVICQINFARKATLRSHFDSVAHQKRASAILESEE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	16/79 (20%)
		COG5048	<264..411	CDD:227381	51/154 (33%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	8/24 (33%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	9/20 (45%)
		zf-H2C2_2	345..367	CDD:290200	9/22 (41%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	9/23 (39%)
		C2H2 Zn finger	386..406	CDD:275368	6/21 (29%)
CG17801	NP_650660.2	zf-AD	9..74	CDD:285071	15/74 (20%)
		zf-C2H2	231..252	CDD:278523	7/20 (35%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		zf-H2C2_2	244..269	CDD:290200	9/24 (38%)
		C2H2 Zn finger	260..281	CDD:275368	5/20 (25%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..362	CDD:275368	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960