DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and CG6808

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001247055.1	Gene:	CG6808 / 41394	FlyBaseID:	FBgn0037921	Length:	375	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	114/414 - (27%)
Similarity:	181/414 - (43%)	Gaps:	57/414 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESNEKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVRCL 68
            |.:.||.:||.|....:  :..|..:|...|    .::|...||..|..||..||::|:.|:..|
  Fly     2 EISIKWSMCRTCRKKGT--QSTLQSLFESNA----HKLLISYAGTSVKPDDGLPDQICTVCLMQL 60

  Fly    69 RLCYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGMKV 133
            ....:|...|::|..|:..::.:..|:|:|         .|.|..:..|:..:....|...|..:
  Fly    61 EEVDRFLSACKQSDAHLRSLVRQTLSSASA---------FETLEDKDQLEQKKRARKQNISGRLI 116

  Fly   134 EGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTN-ENSPEIAQ 197
            |      ...|.:..::...:.|.           .:||.....::....::|..| ||..:|.|
  Fly   117 E------ENPINFKTQENALETTK-----------DDEILPINKFSSDFVFDLNVNAENEKDIHQ 164

  Fly   198 EKGSTGTDVATEEPPEEEIAEDILD---SDEDYDPTHAKPEKC--DRSGRKPVAYHKNSPKVE-T 256
            |              :..|::..||   ||::|..|:::....  |........||...|..: .
  Fly   165 E--------------DYTISDMDLDREISDQNYSETYSQESSAATDSIQETSEDYHNLEPSADYV 215

  Fly   257 FKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNT 321
            ....|..:|    ..|.|.:|.|.|...::|..|.:.|...|.|:||:|.:.|.....|..||.|
  Fly   216 IDLGVACEP----DKYRCKICSNTYRCLSQLNAHSQVHRKEKDHQCEVCQKTFRAACNLKTHMRT 276

  Fly   322 HTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVC 386
            |||.:||:|.||...|||.||..||.|:||.||||.|::|.:||:.|.:...|..:|:.||.|.|
  Fly   277 HTGEKPYQCCYCSRRFADNSTHRKHERLHTNERPYACNICGKTFSLSSSRNAHYYLHSSEKSHKC 341

  Fly   387 DLCGKGFVKAYKLRLHRETHNRRI 410
            .:|.|.|...::|..|.::...|:
  Fly   342 LMCKKEFRLKHQLTAHEKSLAHRL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	21/75 (28%)
		COG5048	<264..411	CDD:227381	58/147 (39%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		zf-H2C2_2	315..338	CDD:290200	12/22 (55%)
		C2H2 Zn finger	330..350	CDD:275368	11/19 (58%)
		zf-H2C2_2	345..367	CDD:290200	13/21 (62%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	8/23 (35%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
CG6808	NP_001247055.1	zf-AD	9..79	CDD:214871	21/75 (28%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		zf-C2H2	255..277	CDD:278523	8/21 (38%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..293	CDD:290200	12/23 (52%)
		C2H2 Zn finger	285..305	CDD:275368	11/19 (58%)
		zf-H2C2_2	299..321	CDD:290200	12/21 (57%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..359	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I3338
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.890