DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trem and nom

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001262384.1	Gene:	nom / 41038	FlyBaseID:	FBgn0037617	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	103/434 - (23%)
Similarity:	162/434 - (37%)	Gaps:	127/434 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VCRVC-----------LNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKC 64
            |||||           |..|...:.|              :.:.:..||.:....|.||.:|..|
  Fly     5 VCRVCGRSRLCPKAVELFKPGRQDIL--------------RRIQLITGILLQQIPNAPDMVCFCC 55

  Fly    65 VRCLRLCYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDG 129
            ...|:....||..|....:..:.:|           :.|.:..:|:..||.     .|.:::...
  Fly    56 QTDLQSAMIFRRQCILQQKKWVPLL-----------QSDKVGASEEKKVEP-----NDPSTKKKT 104

  Fly   130 GMKVEGEEDQQHQVITYVVED------GDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLT 188
            ..:..|......:::..||.:      |::...:.||     |||
  Fly   105 TKRRRGRPRMPLEIVDIVVTNESKASAGESVGGDEFD-----QPV-------------------- 144

  Fly   189 NENSPEIAQEKGSTGTDVATEE--PPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYHKNS 251
                 ||:.|..:|.:||..||  .|:    ||.|:||.|.
  Fly   145 -----EISNEPDATDSDVNLEEIDLPD----EDGLESDHDL------------------------ 176

  Fly   252 PKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLV 316
            |.|:..|               ||.||.|...::.|..|...|:|::|:.|:.|.:.|:...:|.
  Fly   177 PNVQIHK---------------CDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELK 226

  Fly   317 RH-MNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTG 380
            .| :..||...|:.|.||...:.....:.||.|:||.|||:|||.|.:.||.:..||.|..:|..
  Fly   227 AHNLTHHTLEPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCILKAHMAVHQV 291

  Fly   381 EKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKAED 424
            .:.:.||:|.:.|    .|:.|..||....|.:.:||..|.:.:
  Fly   292 VRKYSCDVCDRSF----SLKKHLATHFISNTHKRNAEAVTSSSE 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	19/86 (22%)
		COG5048	<264..411	CDD:227381	47/147 (32%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	8/23 (35%)
		C2H2 Zn finger	302..322	CDD:275368	5/20 (25%)
		zf-H2C2_2	315..338	CDD:290200	8/23 (35%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	345..367	CDD:290200	13/21 (62%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..394	CDD:290200	7/23 (30%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
nom	NP_001262384.1	zf-AD	5..76	CDD:214871	19/84 (23%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		C2H2 Zn finger	212..261	CDD:275368	14/48 (29%)
		zf-H2C2_2	255..278	CDD:290200	13/22 (59%)
		C2H2 Zn finger	269..289	CDD:275368	8/19 (42%)
		zf-H2C2_2	282..305	CDD:290200	8/26 (31%)
		C2H2 Zn finger	297..313	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960