Protein Alignment trem and ZNF790

DIOPT Version :10

• Sequence 1: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: XP_047294754.1
• Gene: ZNF790 / 388536
• HGNCID: 33114
• Length: 670
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 115/439 - (26%)
• Similarity: 185/439 - (42%)
• Gaps: 72/439 - (16%)

  Fly     5 SNEKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVR--C 67
            |.|:|    .||:  .|..:|..|:..|..|..:.  |..|...|.:.......|...|.:|  .
Human    49 SQEEW----ECLD--LEQRDLYRDVMLENYSNMVS--LGFCIYQPEAFSLLEKGKEPWKILRDET 105

  Fly    68 LRLCYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVL--KSWEDYASQLDGG 130
            ...|...:..||..     .:|.:.........:.:::.|.::.|::.:.  ..||       |.
Human   106 RGPCPDMQSRCQTK-----KLLPKNGIFEREIAQLEIMRICKNHSLDCLCFRGDWE-------GN 158

  Fly   131 MKVEGEEDQQHQVITYVVEDGDTDDT----NMFDVHD--PTQPVPNEIEEAE----TYAEYEEYE 185
            .:.:..:|.|.:....|:...:...|    .:|::|.  .|....||.:|..    :.:::.:::
Human   159 TQFQTLQDNQEECFKQVIRTCEKRPTFNQHTVFNLHQRLNTGDKLNEFKELGKAFISGSDHTQHQ 223

  Fly   186 LLTNENSPEIAQEKGSTGTDVATEEPPEEEIAEDILDSDEDYDPTHA--KPEKCDRSG-----RK 243
            |:  ..|.:...:|....|.:     |:.|:.:        |...|.  |..:|...|     |.
Human   224 LI--HTSEKFCGDKECGNTFL-----PDSEVIQ--------YQTVHTVKKTYECKECGKSFSLRS 273

  Fly   244 PVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRG 308
            .:..||   ::.|     |.||      :.|..||..:...::|:.|.:.|:|.|.:||:.||:.
Human   274 SLTGHK---RIHT-----GEKP------FKCKDCGKAFRFHSQLSVHKRIHTGEKSYECKECGKA 324

  Fly   309 FVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKF 373
            |.....|.||...|||.:||:||.|..||:.||...||.||||.|:||.|..|.:.||...:|..
Human   325 FSCGSDLTRHQRIHTGEKPYECNECRKAFSQRSHLIKHQRIHTGEKPYECKECGKAFTRGSHLTQ 389

  Fly   374 HKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKA 422
            |:.||||||.|.|..|||.|::...|..|:..|..|..::  .|:..||
Human   390 HQRIHTGEKSHECKECGKAFIRGSNLAQHQNVHVGRKPYK--CEKCGKA 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	16/77 (21%)
		COG5048	<264..411	CDD:227381	61/146 (42%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	10/19 (53%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
ZNF790	XP_047294754.1	KRAB	39..98	CDD:214630	14/56 (25%)
		C2H2 Zn finger	179..198	CDD:275368	3/18 (17%)
		C2H2 Zn finger	206..226	CDD:275368	2/21 (10%)
		C2H2 Zn finger	235..254	CDD:275368	5/31 (16%)
		C2H2 Zn finger	262..282	CDD:275368	5/22 (23%)
		zf-H2C2_2	278..297	CDD:463886	9/32 (28%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		zf-H2C2_2	303..327	CDD:463886	10/23 (43%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	342..>609	CDD:227381	43/97 (44%)
		C2H2 Zn finger	346..366	CDD:275368	10/19 (53%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		C2H2 Zn finger	430..450	CDD:275368	3/7 (43%)
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		C2H2 Zn finger	514..534	CDD:275368
		C2H2 Zn finger	542..562	CDD:275368
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	598..617	CDD:275368