DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF568

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	474	Identity:	121/474 - (25%)
Similarity:	194/474 - (40%)	Gaps:	100/474 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSK-CVRCLRL 70
            ||.:.|:....        :..:.|:..::|  |..:.|..:...|:.|.......| |||..:.
Human   150 EKVIECKKVAK--------IFPLSSDIVTSR--QSFYDCDSLDKGLEHNLDLLRYEKGCVREKQS 204

  Fly    71 ---------CYKFRLT------CQRSHQHIMDMLDREASNANAAGE--------GDLLSIAEDLS 112
                     |..:.:|      |.:...|..|::..|..:   |||        |...|..|:|.
Human   205 NEFGKPFYHCASYVVTPFKCNQCGQDFSHKFDLIRHERIH---AGEKPYECKECGKAFSRKENLI 266

  Fly   113 VESVLKSWE-DYASQLDGGMKVE-GEEDQQHQVIT----YVVED---GDTDDTNMFD---VHDPT 165
            ....:.:.| .|.....|...:: ....:.|::.|    |..:|   ..:..:|:.:   :|  |
Human   267 THQKIHTGEKPYKCNECGKAFIQMSNLIRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERIH--T 329

  Fly   166 QPVPNEIEE-AETYAEYE---EYELLTNENSPEIAQEKGSTGTDVATEEPPEEEIAEDILDSDED 226
            ...|.|.:| .:::::.:   |:|.:.....|....|.|.               |...:.|...
Human   330 GEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGR---------------AFSRMSSVTL 379

  Fly   227 YDPTHA--KPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTE 289
            :..:|.  ||.||::.|:   |:.:.|..:...:...|.||      |:|..||..:...:.||.
Human   380 HMRSHTGEKPYKCNKCGK---AFSQCSVFIIHMRSHTGEKP------YVCSECGKAFSQSSSLTV 435

  Fly   290 HMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKER 354
            ||:.|:..||:||:.||:.|.:.:.|:.|...|||.:||:|:.|..||...|...:|.||||.|:
Human   436 HMRNHTAEKPYECKECGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEK 500

  Fly   355 PYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEES 419
            ||.|.||.:.|:...||..|:.|||||||:.|:.|||.|.:...|..|.:.|.
Human   501 PYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHT------------ 553

  Fly   420 TKAEDVKGETPEFLNELPK 438
                   ||.|...||..|
Human   554 -------GEKPFKCNECGK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	15/91 (16%)
		COG5048	<264..411	CDD:227381	60/146 (41%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	12/21 (57%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	14/23 (61%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	4/19 (21%)
		zf-H2C2_2	236..261	CDD:290200	6/27 (22%)
		COG5048	248..634	CDD:227381	99/363 (27%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..289	CDD:290200	4/24 (17%)
		C2H2 Zn finger	280..300	CDD:275368	2/19 (11%)
		zf-H2C2_2	292..317	CDD:290200	4/24 (17%)
		C2H2 Zn finger	308..328	CDD:275368	2/19 (11%)
		zf-H2C2_2	320..345	CDD:290200	6/26 (23%)
		C2H2 Zn finger	336..356	CDD:275368	3/19 (16%)
		zf-H2C2_2	348..373	CDD:290200	6/39 (15%)
		C2H2 Zn finger	364..384	CDD:275368	4/34 (12%)
		zf-H2C2_2	380..401	CDD:290200	7/23 (30%)
		C2H2 Zn finger	392..412	CDD:275368	4/22 (18%)
		zf-H2C2_2	408..429	CDD:290200	7/26 (27%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..457	CDD:290200	12/24 (50%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		zf-H2C2_2	460..485	CDD:290200	11/24 (46%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	12/24 (50%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		zf-H2C2_2	516..541	CDD:290200	15/24 (63%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		zf-H2C2_2	544..569	CDD:290200	9/41 (22%)
		C2H2 Zn finger	560..580	CDD:275368	3/6 (50%)
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000