DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF852

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001274278.1	Gene:	ZNF852 / 285346	HGNCID:	27713	Length:	530	Species:	Homo sapiens

Alignment Length:	370	Identity:	95/370 - (25%)
Similarity:	154/370 - (41%)	Gaps:	91/370 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 MLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGM-------------------KV 133
            ||:.:.|.|:..  .:::..:|....:.:.|..|. ::...||:                   ::
Human    37 MLENDRSMASLG--RNMMESSELTPKQEIFKGSES-SNSTSGGLFGVVPGGTETGDVCEDTFKEL 98

  Fly   134 EGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQE 198
            ||:...         |:|...:::..::.|       |.::..|...||||:.:  |..|.::..
Human    99 EGQPSN---------EEGSRLESDFLEIID-------EDKKKSTKDRYEEYKEV--EEHPPLSSS 145

  Fly   199 KGSTGTDVATEEPPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGR 263
                         |.|.  |.:|...:.|        :||..|:   |::.:|..:...:...|.
Human   146 -------------PVEH--EGVLKGQKSY--------RCDECGK---AFYWSSHLIGHRRIHTGE 184

  Fly   264 KPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPY 328
            ||      |.|:.||..:...::|..|::.|:|.||:||..||:.:..:..|::|...|.|.:||
Human   185 KP------YECNECGKTFRQTSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPY 243

  Fly   329 KCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGF 393
            |||.|..||...|....|.|.||.|:||.|..|...|:.|.||..|:.:|||:||:.|:.||:.|
Human   244 KCNECAKAFNQSSKLFDHQRTHTGEKPYECKECGAAFSRSKNLVRHQFLHTGKKPYKCNECGRAF 308

  Fly   394 VKAYKLRLHRETHNRRITWRNDAEESTKAEDVKGETPEFLNELPK 438
            .....|..|:.||.                   ||.|...||..|
Human   309 CSNRNLIDHQRTHT-------------------GEKPYKCNECGK 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	56/146 (38%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	11/23 (48%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
ZNF852	NP_001274278.1	KRAB_A-box	8..47	CDD:143639	4/9 (44%)
		COG5048	156..514	CDD:227381	69/215 (32%)
		C2H2 Zn finger	161..181	CDD:275368	5/22 (23%)
		zf-H2C2_2	177..198	CDD:290200	7/26 (27%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		zf-H2C2_2	202..226	CDD:290200	10/23 (43%)
		C2H2 Zn finger	217..237	CDD:275368	5/19 (26%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	261..282	CDD:290200	10/20 (50%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-C2H2	299..321	CDD:278523	6/21 (29%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	10/41 (24%)
		C2H2 Zn finger	329..349	CDD:275368	3/6 (50%)
		zf-H2C2_2	342..366	CDD:290200
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	370..392	CDD:290200
		C2H2 Zn finger	385..405	CDD:275368
		zf-H2C2_2	398..422	CDD:290200
		C2H2 Zn finger	413..433	CDD:275368
		zf-H2C2_2	425..450	CDD:290200
		C2H2 Zn finger	441..461	CDD:275368
		zf-H2C2_2	453..477	CDD:290200
		C2H2 Zn finger	469..489	CDD:275368
		zf-H2C2_2	482..506	CDD:290200
		C2H2 Zn finger	497..517	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910