DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ace2

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_594109.1	Gene:	ace2 / 2541661	PomBaseID:	SPAC6G10.12c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	282	Identity:	63/282 - (22%)
Similarity:	98/282 - (34%)	Gaps:	77/282 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 FDVHDPTQPVPNEIEEAET---------YAEYEEYELLTNENSPEIAQEKGSTGTDV-------- 206
            |.:..|:...|.::...||         :|:..:.| .|:...|..|.:...:..||
pombe   250 FQISQPSPAHPVDLSSPETAPNISPVSPFAQLVKLE-PTSPQKPSFALDSSFSHLDVCRHTDNQK 313

  Fly   207 --ATEEPPEEEIAE------------DILDSDEDYDPTH--------------AKPEKC------ 237
              |....|.|.::|            ||.:::.:...|.              .|||.|
pombe   314 AFAKLSSPAEYVSEFEKFSSVCDHGLDISNANINNTLTQQFALSAPYESCIVTKKPEPCITVKEE 378

  Fly   238 ----------DRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYIC----DVCGNIYPTQARLT 288
                      |.|....|..|.:.|.|......  |....|.||.||    :...::|.......
pombe   379 EQLAPKIESADLSITPQVTEHDSKPPVRISYDH--RCKTRKQSTRICRIPPETMASLYCGPEADG 441

  Fly   289 EHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKE 353
            :::..::|        |.:...:...:..|:.||..:|||:|:.|.|.|.......:|.|||...
pombe   442 KYVCLYNG--------CNKRIARKYNVESHIQTHLSDRPYRCDLCKAGFVRHHDLKRHLRIHENG 498

  Fly   354 RPYVCDVCSRTFTYSDNLKFHK 375
            |||||: |.:.|...|.|..||
pombe   499 RPYVCE-CLKRFNRLDALNRHK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	33/116 (28%)
		C2H2 Zn finger	274..294	CDD:275368	2/23 (9%)
		zf-H2C2_2	287..311	CDD:290200	2/23 (9%)
		C2H2 Zn finger	302..322	CDD:275368	2/19 (11%)
		zf-H2C2_2	315..338	CDD:290200	9/22 (41%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	345..367	CDD:290200	11/21 (52%)
		C2H2 Zn finger	358..378	CDD:275368	7/18 (39%)
		zf-H2C2_2	370..394	CDD:290200	3/6 (50%)
		C2H2 Zn finger	386..406	CDD:275368
ace2	NP_594109.1	COG5048	45..518	CDD:227381	61/279 (22%)
		C2H2 Zn finger	448..467	CDD:275368	3/26 (12%)
		zf-C2H2	473..495	CDD:278523	7/21 (33%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..511	CDD:290200	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050