DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and Zfp12

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001276518.1	Gene:	Zfp12 / 231866	MGIID:	99157	Length:	686	Species:	Mus musculus

Alignment Length:	414	Identity:	110/414 - (26%)
Similarity:	160/414 - (38%)	Gaps:	108/414 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KTESNEKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVR 66
            :|.|.|:..||..|      |:     .||:.::....|.:|  .|:.:        ..||:|.:
Mouse   367 RTHSGERPYVCHDC------GK-----TFSQKSALNDHQKIH--TGVKL--------YKCSECGK 410

  Fly    67 CLRLCYKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGM 131
            |  .|.|..||     .|:......:....|..|:                     :.|:|
Mouse   411 C--FCRKSTLT-----THMRTHTGEKPYECNECGK---------------------FFSRL---- 443

  Fly   132 KVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIA 196
                    .:..:.|....|:.               |.|..|..     :.:.|    ||..:.
Mouse   444 --------SYLTVHYRTHSGEK---------------PYECAECG-----KSFYL----NSALMR 476

  Fly   197 QEKGSTGTDVATEEPPE-EEIAEDILDSDEDYDPTH------AKPEKCDRSGRKPVAYHKNSPKV 254
            .::..||     |:|.| .|..:  |.|...|...|      .||.:|...|:   .:::||...
Mouse   477 HQRVHTG-----EKPYECNECGK--LFSQLSYLTVHHRTHSGVKPYECSECGK---TFYQNSALC 531

  Fly   255 ETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHM 319
            ...:...|.||      |.|.:||..:...:.||.|.:.|||.||:||..||:.|.||..|.||.
Mouse   532 RHRRIHRGEKP------YECYICGKFFSQMSYLTIHHRIHSGEKPYECRECGKSFCQNSALNRHQ 590

  Fly   320 NTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPH 384
            .||||.:.|:|..|...|:..|..|.|||||:.|:|:.|:.|.:.|:....|..|...|:||||:
Mouse   591 RTHTGEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECNECGKAFSRMSYLTVHHRTHSGEKPY 655

  Fly   385 VCDLCGKGFVKAYKLRLHRETHNR 408
            .|..|||.|........|:.||.|
Mouse   656 ECTECGKKFYHKSAFNSHQRTHRR 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	18/75 (24%)
		COG5048	<264..411	CDD:227381	60/145 (41%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	9/19 (47%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..394	CDD:290200	11/23 (48%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
Zfp12	NP_001276518.1	C2H2 Zn finger	489..509	CDD:275368	5/21 (24%)
		C2H2 Zn finger	517..537	CDD:275368	4/22 (18%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	9/19 (47%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		C2H2 Zn finger	629..649	CDD:275368	5/19 (26%)
		C2H2 Zn finger	657..677	CDD:275368	6/19 (32%)
		KRAB	8..68	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..198
		COG5048	251..677	CDD:227381	107/410 (26%)
		C2H2 Zn finger	265..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368	0/1 (0%)
		C2H2 Zn finger	377..397	CDD:275368	6/30 (20%)
		C2H2 Zn finger	405..425	CDD:275368	9/26 (35%)
		C2H2 Zn finger	433..453	CDD:275368	5/52 (10%)
		C2H2 Zn finger	461..481	CDD:275368	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000