DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and Zfp62

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001349654.1	Gene:	Zfp62 / 22720	MGIID:	99662	Length:	914	Species:	Mus musculus

Alignment Length:	285	Identity:	90/285 - (31%)
Similarity:	129/285 - (45%)	Gaps:	43/285 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 VVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGSTGTDVATEEP 211
            ::::|.:....|.|.|  |.....::|:.:..:|...|. .||.....|..|...|
Mouse    55 ILKEGKSSIREMIDTH--TNAANIKLEQDDETSEKSFYP-STNTMHQTIPTEPNCT--------- 107

  Fly   212 PEEEIAEDILDSDEDYDPTH---AKPEKCDRSGRKPVAYHKNSPKVE------------------ 255
            .:.|..|:|   :.:..|.|   .|..|||..|:   ::..||..|:
Mouse   108 KQGEHTENI---NGNVHPAHIADKKLHKCDECGK---SFKYNSRLVQHKIMHTGEKRYECDDCRG 166

  Fly   256 TFKKKVGRKPRNKLST----YICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLV 316
            ||:.....:...::.|    |.||.||..|.:.:.|..|...|||.|..:|:.||:.|..:..|.
Mouse   167 TFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLD 231

  Fly   317 RHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGE 381
            :|...|||.:||:|..|..||.:.|....|.||||.|:||.||.|.:||:.|..|:.||.|||||
Mouse   232 QHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHTGEKPYECDTCGKTFSNSSGLRVHKRIHTGE 296

  Fly   382 KPHVCDLCGKGFVKAYKLRLHRETH 406
            ||:.||.|||.|:....|..|:..|
Mouse   297 KPYECDECGKAFITCRTLLNHKSIH 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	62/147 (42%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	13/21 (62%)
		C2H2 Zn finger	358..378	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..394	CDD:290200	15/23 (65%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
Zfp62	NP_001349654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..101		4/21 (19%)
		COG5048	127..542	CDD:227381	72/198 (36%)
		C2H2 Zn finger	133..153	CDD:275368	6/22 (27%)
		C2H2 Zn finger	161..181	CDD:275368	2/19 (11%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368
		SFP1	<379..458	CDD:227516
		C2H2 Zn finger	385..405	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368
		COG5048	437..850	CDD:227381
		C2H2 Zn finger	441..461	CDD:275368
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..824	CDD:275368
		C2H2 Zn finger	832..852	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000