DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and Zscan2

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	373	Identity:	105/373 - (28%)
Similarity:	161/373 - (43%)	Gaps:	77/373 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KFRLTCQR-------SHQHIMDMLDRE----ASNANAAGEGDLLSIAEDLSVESVLKSWEDYASQ 126
            :||..|:|       :.:.::.:|.||    ..........:.:::.|||: ::...|  |:..|
Mouse    78 RFRELCRRWLRPEVHTKEQMLTVLPREIQAWLQEHRPESSEEAVALVEDLT-QTFRHS--DFEIQ 139

  Fly   127 LDGG-----------------MKVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEE 174
            .:.|                 :.:.|.|..|.       .|||:|                 .|.
Mouse   140 SENGENSNEDMFEGVESHGMFLNISGGEGGQQ-------SDGDSD-----------------FER 180

  Fly   175 ------AETYAEYEEYELLTNENSPEIAQEKGSTGTDVATEEPPE-EEIAEDILDSDE--DYDPT 230
                  |:.:|..|:..::.:|.. |:.|..|..||.:. |:|.| .:..:.......  .::.|
Mouse   181 DCGSGGAQGHAPGEDPRVVPSEGR-EVGQLIGLQGTYLG-EKPYECPQCGKTFSRKSHLITHERT 243

  Fly   231 HA--KPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKF 293
            |.  |..|||..| |..:...|..:.:|  ...|.||      |.|..||..:...|.|..|.:.
Mouse   244 HTGEKYYKCDECG-KSFSDGSNFSRHQT--THTGEKP------YKCRDCGKSFSRSANLITHQRI 299

  Fly   294 HSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVC 358
            |:|.||.:|..||:.|.::..|:.|..||||.:||.|..|..:|.:||:...|..|||.|:||.|
Mouse   300 HTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEKPYAC 364

  Fly   359 DVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH 406
            ..|..:|:|:.||..|:.|||||||:.|..||:.|.::..|..||.||
Mouse   365 KECGESFSYNSNLIRHQRIHTGEKPYKCTECGQKFSQSSALITHRRTH 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	4/20 (20%)
		COG5048	<264..411	CDD:227381	60/143 (42%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	13/23 (57%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73
		SCAN	69..131	CDD:396558	10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		11/61 (18%)
		COG5048	220..600	CDD:227381	73/202 (36%)
		C2H2 Zn finger	224..244	CDD:275368	0/19 (0%)
		C2H2 Zn finger	252..272	CDD:275368	6/22 (27%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	476..496	CDD:275368
		C2H2 Zn finger	504..524	CDD:275368
		C2H2 Zn finger	532..552	CDD:275368
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910