DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trem and Zfp13

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_011244722.1	Gene:	Zfp13 / 22654	MGIID:	99159	Length:	546	Species:	Mus musculus

Alignment Length:	295	Identity:	83/295 - (28%)
Similarity:	118/295 - (40%)	Gaps:	85/295 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 QPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGSTGTDVATEEPPEEEIA----EDILDSDED 226
            :|.|:|....:|               ||          |...|:|.|.|.|    |:.|..|.|
Mouse   255 KPAPSESRPLKT---------------PE----------DSGPEKPSEGEEALKSGEEGLVPDGD 294

  Fly   227 -----------------------YDPTHA--KPEKCD------------------RSGRKPV--- 245
                                   :..||.  ||..|.                  .:|.||.
Mouse   295 TGKKTYKCEQCGKGFSWHSHLVTHRRTHTGEKPYTCTDCGKRFGRSSHLIQHQIIHTGEKPYTCP 359

  Fly   246 ----AYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICG 306
                ::..:|..::..:...|.||      |:||.|...:..::.|..|...|:|.|||:|.||.
Mouse   360 SCWKSFSHHSTLIQHQRIHTGEKP------YVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICS 418

  Fly   307 RGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNL 371
            :.|.|:..||.|..||||.:||.|..|...|:.||....|:|.||.|:||.|..|.::|::|.:|
Mouse   419 KCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHL 483

  Fly   372 KFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH 406
            ..|:..|.|.:|:.|.||||.|.:...|..|.:.|
Mouse   484 TAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	57/143 (40%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	10/23 (43%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
Zfp13	XP_011244722.1	KRAB	124..179	CDD:214630
		C2H2 Zn finger	302..322	CDD:275368	0/19 (0%)
		zf-H2C2_2	314..339	CDD:372612	5/24 (21%)
		C2H2 Zn finger	330..350	CDD:275368	1/19 (5%)
		zf-H2C2_2	342..367	CDD:372612	3/24 (13%)
		C2H2 Zn finger	358..378	CDD:275368	1/19 (5%)
		COG5048	<360..520	CDD:227381	59/165 (36%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050