DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF485

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	176	Identity:	71/176 - (40%)
Similarity:	99/176 - (56%)	Gaps:	9/176 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 KPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGV 297
            ||.||::.||   |:..||..:|..|...|.||      |.|:.||..:...:.|..|.:.|:|.
Human   268 KPFKCNKCGR---AFRDNSTVLEHQKIHTGEKP------YQCNECGKAFRKSSTLISHQRMHTGE 323

  Fly   298 KPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCS 362
            ||:.|..||:.|..:.....|..||:||:||:|..|..||...||.|.|.||||.|:||.|..|.
Human   324 KPYHCSKCGKSFRYSSSFAGHQKTHSGNKPYQCRDCGKAFTKSSTLTGHQRIHTGEKPYHCKKCG 388

  Fly   363 RTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNR 408
            :.|.:|..|..|:.:||||||:.|:.|||.|.::..|:.|::.||:
Human   389 KAFRHSSGLVEHQRLHTGEKPYKCNECGKAFPRSSALKQHKKIHNK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	59/145 (41%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	9/19 (47%)
		zf-H2C2_2	345..367	CDD:290200	11/21 (52%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	12/23 (52%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<124..361	CDD:227381	37/101 (37%)
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368
		zf-H2C2_2	229..253	CDD:290200
		C2H2 Zn finger	244..264	CDD:275368
		zf-H2C2_2	256..279	CDD:290200	6/13 (46%)
		C2H2 Zn finger	272..292	CDD:275368	8/22 (36%)
		zf-H2C2_2	287..307	CDD:290200	9/25 (36%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		zf-H2C2_2	313..337	CDD:290200	10/23 (43%)
		C2H2 Zn finger	328..348	CDD:275368	5/19 (26%)
		C2H2 Zn finger	356..376	CDD:275368	9/19 (47%)
		zf-H2C2_2	372..393	CDD:290200	11/20 (55%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..419	CDD:290200	12/21 (57%)
		C2H2 Zn finger	412..432	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910