DRSC/TRiP Functional Genomics Resources

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Protein Alignment trem and Zkscan2

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001074798.1 Gene:Zkscan2 / 210162 MGIID:2444060 Length:960 Species:Mus musculus


Alignment Length:455 Identity:115/455 - (25%)
Similarity:179/455 - (39%) Gaps:99/455 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 DIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKCVRCLRLC----------YKFRLTCQRSH 82
            ||..|   ||..:.|..|         :...|:.......||.|          .||: :.|:|:
Mouse   503 DILQE---TRFYEALQAC---------HRKSKLYGVVAEQLRECGFLRTPEQCRTKFK-SLQKSY 554

  Fly    83 QHI--------------MDML--DREAS-NANAAGEGDLLSIAEDLSVESVLK---SWEDYASQL 127
            :.:              ||.|  .|.:| :.|.:.|...||..|...:|...:   :||...:..
Mouse   555 RKVKNGHVLESCAFYKEMDALVNCRPSSLSTNTSEEVPSLSRQERGHIEVEPREPTTWEPVETPQ 619

  Fly   128 DGGMKVEGEEDQQHQVITYVVEDGDTDDTN-------MFDV-----HDPTQPV------------ 168
            :..::..|.|....:   .::|:.:.:..:       .|::     .||||.:            
Mouse   620 EAVLEDSGSERLSEE---EMIEEPELEGPSGLLQSPAGFEIGTIIKEDPTQVMFKDTEPHRVLME 681

  Fly   169 -PNEIEEAET----YAEYEEYELLTNENSPEIAQEK-----GSTGTDVATEEPPEEEIAEDILDS 223
             |..:....|    |.:.|.:.....||...:.|.|     ..||..|..:.|........:|..
Mouse   682 KPKRLVSQNTNPSKYCKREYFSGRHCENLQGVRQGKLMSQPRDTGKAVVHQRPCVGRRPYRLLKY 746

  Fly   224 DEDYD--------PTHAK--PEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCG 278
            .|::.        .||.|  |.||...|:   .:.::...:...:...|.||      :.|..||
Mouse   747 GENFGRSARLVCRMTHQKENPFKCGVCGK---CFGRSRSLIRHQRIHTGEKP------FKCPDCG 802

  Fly   279 NIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTK 343
            ..:...:....|.:.|:|.||:.|..||:.|.|:..|:.|..||||.:||:|..|..:|.:.|..
Mouse   803 KSFNDSSNFGAHQRVHTGEKPYRCRECGKCFSQSSSLIIHQRTHTGEKPYQCEECGKSFTNSSHF 867

  Fly   344 TKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNR 408
            :.|.||||:|.||.|..|.::|......:.|:.||.||||:.|..|||.|.|:..|..|||.|.|
Mouse   868 SAHRRIHTEENPYKCGDCEKSFNNCARFREHQRIHNGEKPYTCAQCGKHFNKSSFLTKHREVHMR 932

  Fly   409  408
            Mouse   933  932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871 15/82 (18%)
COG5048 <264..411 CDD:227381 57/145 (39%)
C2H2 Zn finger 274..294 CDD:275368 4/19 (21%)
zf-H2C2_2 287..311 CDD:290200 9/23 (39%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
zf-H2C2_2 315..338 CDD:290200 10/22 (45%)
C2H2 Zn finger 330..350 CDD:275368 6/19 (32%)
zf-H2C2_2 345..367 CDD:290200 11/21 (52%)
C2H2 Zn finger 358..378 CDD:275368 4/19 (21%)
zf-H2C2_2 370..394 CDD:290200 11/23 (48%)
C2H2 Zn finger 386..406 CDD:275368 10/19 (53%)
Zkscan2NP_001074798.1 SCAN 42..148 CDD:128708
SCAN 42..129 CDD:280241
KRAB <241..282 CDD:214630
Myb_DNA-bind_4 334..415 CDD:290549
ABC_trans_N <466..505 CDD:291196 1/1 (100%)
Myb_DNA-bind_4 490..571 CDD:290549 15/80 (19%)
COG5048 <766..915 CDD:227381 52/157 (33%)
zf-C2H2 768..790 CDD:278523 3/24 (13%)
C2H2 Zn finger 770..790 CDD:275368 2/22 (9%)
zf-H2C2_2 782..806 CDD:290200 6/29 (21%)
C2H2 Zn finger 798..818 CDD:275368 4/19 (21%)
zf-H2C2_2 814..835 CDD:290200 9/20 (45%)
C2H2 Zn finger 826..846 CDD:275368 7/19 (37%)
zf-H2C2_2 838..863 CDD:290200 11/24 (46%)
C2H2 Zn finger 854..874 CDD:275368 6/19 (32%)
zf-H2C2_2 866..891 CDD:290200 11/24 (46%)
C2H2 Zn finger 882..902 CDD:275368 4/19 (21%)
zf-H2C2_2 895..918 CDD:290200 11/22 (50%)
C2H2 Zn finger 910..930 CDD:275368 10/19 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 151 1.000 Inparanoid score I4340
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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