DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF721

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	289	Identity:	87/289 - (30%)
Similarity:	127/289 - (43%)	Gaps:	41/289 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 YAEYEEYELLTNENSPEIAQEKG---STGTD------VATEEPP----EEEIAEDILDSDEDYDP 229
            |....:::.:.....|...:|.|   ::.|:      :.|.|.|    :...|..:..:..:|..
Human   373 YTALNQHKKIHTGEKPYKCEECGKAFNSSTNLTAHKRIHTREKPYTCEDRGRAFGLSTNLNEYKK 437

  Fly   230 THA--KPEKCDRSGRKPV-AYHKNS-PKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEH 290
            .|.  ||.||...|:..: :.|.|. .|:.|     |:||      |.|..||.:..:.:...:|
Human   438 IHTGDKPYKCKECGKAFIHSLHLNKHEKIHT-----GKKP------YKCKQCGKVITSSSSFAKH 491

  Fly   291 MKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERP 355
            .:.|:|.||.||..||:.|..:..|.:|...|||.:||.|..|..||...:....|.||||.|:|
Human   492 KRIHTGEKPFECLECGKAFTSSTTLTKHRRIHTGEKPYTCEVCGKAFRQSAILYVHRRIHTGEKP 556

  Fly   356 YVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH-----------NRR 409
            |.|:.|.:||..|.||..|:.|||||||:.|:.|||.|.:...|..|::.|           .:.
Human   557 YTCEECGKTFRQSANLYVHRRIHTGEKPYKCEECGKAFGRYTDLNQHKKIHTGEKLYKCEECGKD 621

  Fly   410 ITWRNDAEESTKAEDVKGETPEFLNELPK 438
            ..|..|..:..|.  ..||.|....|..|
Human   622 FVWYTDLNQQKKI--YTGEKPYKCEECGK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	58/157 (37%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	345..367	CDD:290200	12/21 (57%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..394	CDD:290200	14/23 (61%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	27/129 (21%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368	1/9 (11%)
		zf-H2C2_2	375..400	CDD:290200	3/24 (13%)
		C2H2 Zn finger	391..411	CDD:275368	3/19 (16%)
		COG5048	442..885	CDD:227381	76/220 (35%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		zf-H2C2_2	487..512	CDD:290200	10/24 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		zf-H2C2_2	516..540	CDD:290200	11/23 (48%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..568	CDD:290200	12/23 (52%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		zf-H2C2_2	571..596	CDD:290200	15/24 (63%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..634	CDD:275368	2/18 (11%)
		C2H2 Zn finger	643..663	CDD:275368	2/6 (33%)
		C2H2 Zn finger	671..691	CDD:275368
		zf-H2C2_2	683..708	CDD:290200
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		zf-H2C2_2	767..789	CDD:290200
		C2H2 Zn finger	783..803	CDD:275368
		zf-H2C2_2	795..820	CDD:290200
		C2H2 Zn finger	811..831	CDD:275368
		zf-H2C2_2	824..848	CDD:290200
		C2H2 Zn finger	839..859	CDD:275368
		zf-H2C2_2	852..876	CDD:290200
		C2H2 Zn finger	867..887	CDD:275368
		C2H2 Zn finger	895..915	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000