DRSC/TRiP Functional Genomics Resources

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Protein Alignment trem and ZNF558

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_653294.1 Gene:ZNF558 / 148156 HGNCID:26422 Length:402 Species:Homo sapiens


Alignment Length:185 Identity:67/185 - (36%)
Similarity:98/185 - (52%) Gaps:17/185 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 THAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLST----YICDVCGNIYPTQARLTEH 290
            |..||.:|::      .:|       .|:.....|...::.|    :.|:.||..:.|::.||.|
Human   231 TGEKPYECNQ------CFH-------VFRTSCNLKSHKRIHTGENHHECNQCGKAFSTRSSLTGH 282

  Fly   291 MKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERP 355
            ...|:|.||:||..||:.|.::..|.:|:.||||.:||:||.|..:|:...:.|.|.||||.|:|
Human   283 NSIHTGEKPYECHDCGKTFRKSSYLTQHVRTHTGEKPYECNECGKSFSSSFSLTVHKRIHTGEKP 347

  Fly   356 YVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRI 410
            |.|..|.:.|.....:|.|...||||||:.|:.|||.|.....|.:|:..|||.|
Human   348 YECSDCGKAFNNLSAVKKHLRTHTGEKPYECNHCGKSFTSNSYLSVHKRIHNRWI 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 61/151 (40%)
C2H2 Zn finger 274..294 CDD:275368 7/19 (37%)
zf-H2C2_2 287..311 CDD:290200 12/23 (52%)
C2H2 Zn finger 302..322 CDD:275368 6/19 (32%)
zf-H2C2_2 315..338 CDD:290200 11/22 (50%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
zf-H2C2_2 345..367 CDD:290200 11/21 (52%)
C2H2 Zn finger 358..378 CDD:275368 5/19 (26%)
zf-H2C2_2 370..394 CDD:290200 12/23 (52%)
C2H2 Zn finger 386..406 CDD:275368 7/19 (37%)
ZNF558NP_653294.1 KRAB 43..100 CDD:214630
C2H2 Zn finger 154..174 CDD:275368
COG5048 <162..398 CDD:227381 63/179 (35%)
C2H2 Zn finger 182..202 CDD:275368
C2H2 Zn finger 210..230 CDD:275368
C2H2 Zn finger 238..258 CDD:275368 4/32 (13%)
C2H2 Zn finger 266..286 CDD:275368 7/19 (37%)
C2H2 Zn finger 294..314 CDD:275368 6/19 (32%)
C2H2 Zn finger 322..342 CDD:275368 7/19 (37%)
C2H2 Zn finger 350..370 CDD:275368 5/19 (26%)
C2H2 Zn finger 378..398 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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