DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trem and ZNF599

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001007249.1 Gene:ZNF599 / 148103 HGNCID:26408 Length:588 Species:Homo sapiens


Alignment Length:209 Identity:73/209 - (34%)
Similarity:96/209 - (45%) Gaps:28/209 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 THAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFH 294
            |..||.:|...|:   |:...|..:...:...|.||      :.|..||..:...:.|.:||:.|
Human   390 TGEKPYECGECGK---AFTHRSTFIRHKRTHTGEKP------FECKECGKAFCDSSSLIQHMRIH 445

  Fly   295 SGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCD 359
            :|.||:||..||:.|..:...:||..||:|.:|.:|..|..||...|:.|:|.||||.|:||||.
Human   446 TGEKPYECSECGKAFTHHSVFIRHNRTHSGQKPLECKECAKAFYYSSSFTRHMRIHTGEKPYVCR 510

  Fly   360 VCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKAED 424
            .|.:.||...|...|..|||||||..|..|.|.|...:.|..|..||.                 
Human   511 ECGKAFTQPANFVRHNRIHTGEKPFECKECEKAFCDNFALTQHMRTHT----------------- 558

  Fly   425 VKGETPEFLNELPK 438
              ||.|...||..|
Human   559 --GEKPFECNECGK 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 59/146 (40%)
C2H2 Zn finger 274..294 CDD:275368 6/19 (32%)
zf-H2C2_2 287..311 CDD:290200 12/23 (52%)
C2H2 Zn finger 302..322 CDD:275368 6/19 (32%)
zf-H2C2_2 315..338 CDD:290200 9/22 (41%)
C2H2 Zn finger 330..350 CDD:275368 8/19 (42%)
zf-H2C2_2 345..367 CDD:290200 12/21 (57%)
C2H2 Zn finger 358..378 CDD:275368 6/19 (32%)
zf-H2C2_2 370..394 CDD:290200 12/23 (52%)
C2H2 Zn finger 386..406 CDD:275368 6/19 (32%)
ZNF599NP_001007249.1 KRAB 9..69 CDD:214630
KRAB 9..48 CDD:279668
C2H2 Zn finger 201..221 CDD:275368
C2H2 Zn finger 229..249 CDD:275368
zf-H2C2_2 244..266 CDD:290200
COG5048 253..>580 CDD:227381 73/209 (35%)
C2H2 Zn finger 257..277 CDD:275368
zf-H2C2_2 269..294 CDD:290200
C2H2 Zn finger 285..305 CDD:275368
C2H2 Zn finger 313..333 CDD:275368
zf-H2C2_2 325..350 CDD:290200
C2H2 Zn finger 341..361 CDD:275368
C2H2 Zn finger 369..389 CDD:275368
zf-H2C2_2 381..406 CDD:290200 6/18 (33%)
C2H2 Zn finger 397..417 CDD:275368 4/22 (18%)
zf-H2C2_2 412..432 CDD:290200 6/25 (24%)
C2H2 Zn finger 425..445 CDD:275368 6/19 (32%)
zf-H2C2_2 437..462 CDD:290200 12/24 (50%)
C2H2 Zn finger 453..473 CDD:275368 6/19 (32%)
C2H2 Zn finger 481..501 CDD:275368 8/19 (42%)
zf-H2C2_2 493..518 CDD:290200 13/24 (54%)
C2H2 Zn finger 509..529 CDD:275368 6/19 (32%)
zf-H2C2_2 521..544 CDD:290200 12/22 (55%)
C2H2 Zn finger 537..557 CDD:275368 6/19 (32%)
zf-H2C2_2 549..574 CDD:290200 10/41 (24%)
C2H2 Zn finger 565..585 CDD:275368 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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