DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trem and ZNF572

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_689625.2 Gene:ZNF572 / 137209 HGNCID:26758 Length:529 Species:Homo sapiens


Alignment Length:329 Identity:89/329 - (27%)
Similarity:152/329 - (46%) Gaps:50/329 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 EDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGS 201
            ||.:...:|:|.::....|:  ::....::...|.|.:.|....::|::  :.|::....|:..|
Human    66 EDAKEMPLTWVQDEIWCHDS--YESDGKSENWGNFIAKEEEKPNHQEWD--SGEHTNACVQQNSS 126

  Fly   202 TGTDVATEEPPE-EEIAEDILDSD--EDYDPTHA--KPEKCD------------------RSGRK 243
                 ..:.|.: .|..:...:|.  ..:..||:  ||.||.                  .:|.|
Human   127 -----FVDRPYKCSECWKSFSNSSHLRTHQRTHSGEKPYKCSECAKCFCNSSHLIQHLRMHTGEK 186

  Fly   244 PV-------AYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHE 301
            |.       ::...|..:...:...|.||      |.|..||..:.:.:.|.:|.:.|:|.||:|
Human   187 PYQCGECGKSFSNTSHLIIHERTHTGEKP------YKCPECGKRFSSSSHLIQHHRSHTGEKPYE 245

  Fly   302 CEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFT 366
            |.:||:||..:..|:.|..||||.:||||..|..:|:..|:..:|.|.||.|:||.|..|.::|.
Human   246 CSVCGKGFSHSYVLIEHQRTHTGEKPYKCPDCGKSFSQSSSLIRHQRTHTGEKPYKCLECEKSFG 310

  Fly   367 YSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKAEDVKGETPE 431
            .:..|..|:.|||||||:.|..|||.|.::..|..|::.|....::     ||::.|:..|:...
Human   311 CNSTLIKHQRIHTGEKPYQCPECGKNFSRSSNLITHQKMHTGEKSY-----ESSEYEESLGQNCN 370

  Fly   432 FLNE 435
            .:.|
Human   371 VIEE 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 58/146 (40%)
C2H2 Zn finger 274..294 CDD:275368 5/19 (26%)
zf-H2C2_2 287..311 CDD:290200 12/23 (52%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
zf-H2C2_2 315..338 CDD:290200 11/22 (50%)
C2H2 Zn finger 330..350 CDD:275368 6/19 (32%)
zf-H2C2_2 345..367 CDD:290200 10/21 (48%)
C2H2 Zn finger 358..378 CDD:275368 5/19 (26%)
zf-H2C2_2 370..394 CDD:290200 13/23 (57%)
C2H2 Zn finger 386..406 CDD:275368 7/19 (37%)
ZNF572NP_689625.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
COG5048 122..494 CDD:227381 79/269 (29%)
C2H2 Zn finger 134..154 CDD:275368 2/19 (11%)
C2H2 Zn finger 162..182 CDD:275368 1/19 (5%)
C2H2 Zn finger 190..210 CDD:275368 1/19 (5%)
C2H2 Zn finger 218..238 CDD:275368 5/19 (26%)
C2H2 Zn finger 246..266 CDD:275368 7/19 (37%)
C2H2 Zn finger 274..294 CDD:275368 6/19 (32%)
C2H2 Zn finger 302..322 CDD:275368 5/19 (26%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
C2H2 Zn finger 386..406 CDD:275368
C2H2 Zn finger 414..434 CDD:275368
C2H2 Zn finger 442..462 CDD:275368
C2H2 Zn finger 470..490 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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