DRSC/TRiP Functional Genomics Resources

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Protein Alignment trem and ZNF526

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001300962.1 Gene:ZNF526 / 116115 HGNCID:29415 Length:670 Species:Homo sapiens


Alignment Length:471 Identity:101/471 - (21%)
Similarity:152/471 - (32%) Gaps:190/471 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 KCVRCLRLC---YKFRLTCQRSHQHIMDMLDREASNANAAGEGDLLSIAEDLSVESVLKSWEDYA 124
            :|..|..||   .:| |..|.:|   .|.|::|..|                             
Human   198 ECPECSTLCATPEEF-LEHQGTH---FDSLEKEERN----------------------------- 229

  Fly   125 SQLDGGMKVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTN 189
                 |::.|.|:|:         ||.:.|:               |:|:.|..||..:..:..:
Human   230 -----GLEEEEEDDE---------EDEEDDE---------------EMEDEEAMAEVGDDAVGGD 265

  Fly   190 ENSPEIAQEKGSTGTDVATEEPPEEEIAEDILDSDEDYDPTHAKP---EKCDRS----------G 241
            |::...||..|    |....:|......:....:......||  |   .:|.||          |
Human   266 ESTAGWAQGCG----DCPQHQPSAGARRQHRRTAHSPASATH--PFHCSQCQRSFSSANRLQAHG 324

  Fly   242 RKPV-AYHKNSPKVETFKKKVGRKPRNKL----STYICDVCGNIYPTQARLTEHMKFH------- 294
            |..| ..|:.:...:.|||....:...:|    :.|:|..||..:.|:..|..|.:.|       
Human   325 RAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHR 389

  Fly   295 -----------------------SGVKP------------------------------------- 299
                                   ||..|                                     
Human   390 CRCGKTFSNMTKFLYHRRTHAGKSGAPPTGATAPPAPAEPTPPPPPPAPPAQLPCPQCSKSFASA 454

  Fly   300 -----------------HECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHH 347
                             |.|.:||:||.:...:..|:.||||.||::|:.|...||..:..::|.
Human   455 SRLSRHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQ 519

  Fly   348 RIHTKERPYVCDVCSRTFTYSDNLKFHKMIH--------------TG---EKPHVCDLCGKGFVK 395
            ..||..|||.|..|.:.||.|.||:.|:.:|              ||   :.|:.|..||:.|..
Human   520 LTHTGARPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRA 584

  Fly   396 AYKLRLHRETHNRRIT 411
            ...||||:..|.|..|
Human   585 MAGLRLHQRVHARART 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871 8/26 (31%)
COG5048 <264..411 CDD:227381 57/251 (23%)
C2H2 Zn finger 274..294 CDD:275368 6/19 (32%)
zf-H2C2_2 287..311 CDD:290200 12/107 (11%)
C2H2 Zn finger 302..322 CDD:275368 6/19 (32%)
zf-H2C2_2 315..338 CDD:290200 9/22 (41%)
C2H2 Zn finger 330..350 CDD:275368 5/19 (26%)
zf-H2C2_2 345..367 CDD:290200 9/21 (43%)
C2H2 Zn finger 358..378 CDD:275368 8/19 (42%)
zf-H2C2_2 370..394 CDD:290200 10/40 (25%)
C2H2 Zn finger 386..406 CDD:275368 8/19 (42%)
ZNF526NP_001300962.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..196
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..304 25/153 (16%)
C2H2 Zn finger 275..296 CDD:275368 3/24 (13%)
C2H2 Zn finger 307..327 CDD:275368 5/19 (26%)
C2H2 Zn finger 334..354 CDD:275368 3/19 (16%)
C2H2 Zn finger 362..382 CDD:275368 6/19 (32%)
C2H2 Zn finger 390..409 CDD:275368 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..443 3/33 (9%)
COG5048 <441..550 CDD:227381 31/108 (29%)
C2H2 Zn finger 444..464 CDD:275368 0/19 (0%)
C2H2 Zn finger 474..494 CDD:275368 6/19 (32%)
zf-H2C2_2 486..511 CDD:290200 10/24 (42%)
C2H2 Zn finger 502..522 CDD:275368 5/19 (26%)
zf-H2C2_2 514..539 CDD:290200 9/24 (38%)
C2H2 Zn finger 530..550 CDD:275368 8/19 (42%)
C2H2 Zn finger 575..595 CDD:275368 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..621 101/471 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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