DRSC/TRiP Functional Genomics Resources

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Protein Alignment trem and ZNF275

DIOPT Version :9

Sequence 1:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001354686.1 Gene:ZNF275 / 10838 HGNCID:13069 Length:429 Species:Homo sapiens


Alignment Length:381 Identity:96/381 - (25%)
Similarity:149/381 - (39%) Gaps:79/381 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 EGDLLSIAEDLSVESVLKSWEDYASQLDGGMKVEGEEDQQHQVITYVVEDGDTDDTNMFDVHDPT 165
            :|.:| :..|.|..:....:.:..|.....||.|..:.|:....::....|.:.:.......|..
Human    25 QGQVL-LVSDPSPNTDPAKYSESTSATRHQMKGEDAQPQEMASTSFPRASGPSPEFRQHGDSDGK 88

  Fly   166 QPVPNEIEEAETYAEYE-----EYELLTNENSPEIAQEKGSTGTD------------------VA 207
            :..|..:.....:|..|     ..::|..::....::|||....|                  ||
Human    89 RGSPQNLPIEHHFACKECGDTFRLKVLLVQHQRVHSEEKGWECGDCGKVFRGVAEFNEHRKSHVA 153

  Fly   208 TE-EPPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYHKN--------------------- 250
            .| :|......|:..:..|..: ..|||.:|:..|::   :.||                     
Human   154 AEPQPGPSRALENAAEKREQME-REAKPFECEECGKR---FKKNAGLSQHLRVHSREKPFDCEEC 214

  Fly   251 --SPKVETF-----KKKVGRKP------------------RNKLST----YICDVCGNIYPTQAR 286
              |.||.|.     |.....||                  ..::.|    :.||.||..:.....
Human   215 GRSFKVNTHLFRHQKLHTSEKPFACKACSRDFLDRQELLKHQRMHTGHLPFDCDDCGKSFRGVNG 279

  Fly   287 LTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHT 351
            |.||.:.|||.||:.|..||:.|.::.:|.:|...|||.:||.|..|..||...|:..:|.|||:
Human   280 LAEHQRIHSGAKPYGCPHCGKLFRRSSELTKHRRIHTGEKPYACGQCGKAFRQSSSLLEHARIHS 344

  Fly   352 KERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHN 407
            .||||.|..|.:.|....:|..|:.||:|.||:.||.|||.|.::..|..||..|:
Human   345 GERPYACGECGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSRHRRIHS 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 59/166 (36%)
C2H2 Zn finger 274..294 CDD:275368 7/19 (37%)
zf-H2C2_2 287..311 CDD:290200 12/23 (52%)
C2H2 Zn finger 302..322 CDD:275368 6/19 (32%)
zf-H2C2_2 315..338 CDD:290200 10/22 (45%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
zf-H2C2_2 345..367 CDD:290200 11/21 (52%)
C2H2 Zn finger 358..378 CDD:275368 5/19 (26%)
zf-H2C2_2 370..394 CDD:290200 12/23 (52%)
C2H2 Zn finger 386..406 CDD:275368 9/19 (47%)
ZNF275NP_001354686.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..95 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..176 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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