Protein Alignment trem and ZNF234

DIOPT Version :10

• Sequence 1: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_006621.1
• Gene: ZNF234 / 10780
• HGNCID: 13027
• Length: 700
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 67/197 - (34%)
• Similarity: 102/197 - (51%)
• Gaps: 20/197 - (10%)

  Fly   230 THAKPEKCDRSGRKPVAYHKNSPKVETFKKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHMKFH 294
            |..||.||:..|:   .:.:.:......:...|.||      |.|:.||.::...:.|..|.:.|
Human   479 TGEKPYKCEECGK---GFSRRADLKIHCRIHTGEKP------YNCEECGKVFSQASHLLTHQRVH 534

  Fly   295 SGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCD 359
            ||.||.:||.||:.|.::..|..|...|||.:||||..|...|........|.|:||.|:||.|.
Human   535 SGEKPFKCEECGKSFSRSAHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCG 599

  Fly   360 VCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH-----------NRRITWR 413
            .|.:.|:.:.:|:.|:.:||||||:.||:|||.|.::.:|:.||..|           .:|.:||
Human   600 ECGKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRFSWR 664

  Fly   414 ND 415
            ::
Human   665 SN 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	58/157 (37%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
ZNF234	NP_006621.1	KRAB	8..65	CDD:214630
		KRNB	91..147
		COG5048	<101..306	CDD:227381
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		SUF4-like	202..>251	CDD:411020
		C2H2 Zn finger	203..231	CDD:411020
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368
		C2H2 Zn finger	234..251	CDD:411020
		COG5048	258..672	CDD:227381	67/197 (34%)
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	290..310	CDD:275368
		C2H2 Zn finger	318..338	CDD:275368
		C2H2 Zn finger	346..366	CDD:275368
		C2H2 Zn finger	374..394	CDD:275368
		C2H2 Zn finger	402..422	CDD:275368
		C2H2 Zn finger	430..450	CDD:275368
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368	2/22 (9%)
		C2H2 Zn finger	514..534	CDD:275368	5/19 (26%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..618	CDD:275368	5/19 (26%)
		C2H2 Zn finger	626..646	CDD:275368	9/19 (47%)
		C2H2 Zn finger	654..674	CDD:275368	3/13 (23%)