DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trem and ZNF891

DIOPT Version :9

Sequence 1:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001264220.1	Gene:	ZNF891 / 101060200	HGNCID:	38709	Length:	544	Species:	Homo sapiens

Alignment Length:	425	Identity:	118/425 - (27%)
Similarity:	167/425 - (39%)	Gaps:	111/425 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EELLHDIFSETASTRLDQMLHICAGIPVSLDDNFPDKMCSKC---VRCLRLCYKFRLTCQRSHQH 84
            :||..|......:::|...|.....|       |..|.|.||   :.||:            |..
Human   185 QELFRDYHELEENSKLGSKLIFSQSI-------FTSKHCQKCYSEIGCLK------------HNS 230

  Fly    85 IMDMLDREASNANAAGEGDLLSIAEDL--SVESVLKSWEDYASQLDGGMKVEGEEDQQHQVITYV 147
            |::...:.             ||:|.|  |.|.....|....:|     .|:.|       .||
Human   231 IINNYVKN-------------SISEKLYESHECDTTLWHFQRNQ-----TVQKE-------YTY- 269

  Fly   148 VEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGSTGTDVATEEPP 212
            .:.|.....|||       ||||.:..|:...|..:.|.|.:::|   .:::|.|.|:
Human   270 SKHGMHFTHNMF-------PVPNNLHMAQNACECNKDETLCHQSS---LKKQGQTHTE------- 317

  Fly   213 EEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYHKNSPKVETFKKK-VGRKPRNKLSTYICDV 276
                                |..:|::.|:.    .|....:..:||. :|.|      .|.|..
Human   318 --------------------KKHECNQCGKA----FKRISNLTLYKKSHMGEK------QYECKE 352

  Fly   277 CGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRS 341
            ||.::...:.|..|::.|:|.||:||..||:.|.|...|..||.||||.:||:||.|..:|...|
Human   353 CGKVFNDSSTLRRHVRTHTGEKPYECNQCGKAFSQKTSLKAHMRTHTGEKPYECNQCGKSFGTSS 417

  Fly   342 TKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETH 406
            ....|.||||.|:.|.|..|.:.|..|.:||.||.|||||..:.|..|||.|.....||:|..||
Human   418 YLIVHKRIHTGEKLYECSECGKAFNTSSHLKVHKKIHTGENVYECSDCGKVFSGVSSLRMHIRTH 482

  Fly   407 NRRITWRNDAEESTKAEDVK-----------GETP 430
            .....:  :.:|..||..|.           ||.|
Human   483 TGEKPY--ECKECRKAFSVSSSLRRHVRIHTGEKP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trem	NP_650861.1	zf-AD	11..87	CDD:214871	15/66 (23%)
		COG5048	<264..411	CDD:227381	61/146 (42%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..338	CDD:290200	12/22 (55%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..394	CDD:290200	13/23 (57%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
ZNF891	NP_001264220.1	KRAB	43..99	CDD:214630
		KRAB	43..82	CDD:279668
		COG5048	<272..544	CDD:227381	91/293 (31%)
		C2H2 Zn finger	295..315	CDD:275368	5/22 (23%)
		C2H2 Zn finger	322..342	CDD:275368	5/23 (22%)
		zf-C2H2	348..370	CDD:278523	6/21 (29%)
		C2H2 Zn finger	350..370	CDD:275368	5/19 (26%)
		zf-H2C2_2	363..387	CDD:290200	11/23 (48%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		zf-H2C2_2	390..415	CDD:290200	13/24 (54%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..443	CDD:290200	10/24 (42%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		zf-H2C2_2	446..470	CDD:290200	13/23 (57%)
		C2H2 Zn finger	462..482	CDD:275368	8/19 (42%)
		zf-H2C2_2	474..498	CDD:290200	8/25 (32%)
		C2H2 Zn finger	490..510	CDD:275368	4/19 (21%)
		zf-H2C2_2	502..527	CDD:290200	3/14 (21%)
		C2H2 Zn finger	518..538	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000