Protein Alignment CG4854 and ZKSCAN3

DIOPT Version :10

• Sequence 1: NP_650860.1
• Gene: CG4854 / 42391
• FlyBaseID: FBgn0038766
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_077819.2
• Gene: ZKSCAN3 / 80317
• HGNCID: 13853
• Length: 538
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 87/337 - (25%)
• Similarity: 143/337 - (42%)
• Gaps: 72/337 - (21%)

  Fly     2 HTNVDSRDLKCRICLV-------------------QPKDESLMPTEPDFPDKIKRCTGVELSESP 47
            |.:|.|:.|:.|:..|                   .|:.:.|:..|           .|.|:.:|
Human   172 HESVGSQPLQDRVLQVPVLAHGGCCREDKVVASRLTPESQGLLKVE-----------DVALTLTP 225

  Fly    48 DWPNRICTSCALLLRAALKLRSLCQQTEKDLKEQKLQEINIEIVHDEQETKKKTESRDLSKNEAT 112
            :|..:..:.           .:||:. ||......|..:.     ||::||    ||||...|
Human   226 EWTQQDSSQ-----------GNLCRD-EKQENHGSLVSLG-----DEKQTK----SRDLPPAE-- 267

  Fly   113 GSDSELEYEYLDSYDVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFEDEDSGQAAS 177
                          ::..:....::|...|.::..|..:...|....|..|     .:::.....
Human   268 --------------ELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRK-----QKNATGGRR 313

  Fly   178 FTCNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSR 242
            ..|:.|...:::...|:.|.::|:.:||:|||.|.|.|..:..|..|...|||.:||:|:.|...
Human   314 HICHECGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKA 378

  Fly   243 FADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNS 307
            |:..|..|||||.||.|:||:|:.|.::|..|..|..|.:.||||:|:.|..|.|:|.:..|...
Human   379 FSHSSDLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLR 443

  Fly   308 HEKSHKRTKEVK 319
            |::.|...|.|:
Human   444 HQRIHTGDKNVQ 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:214871	9/63 (14%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	201..>258	CDD:227381	25/56 (45%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:463886	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..271	CDD:463886	11/19 (58%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZKSCAN3	NP_077819.2	SCAN	42..154	CDD:128708
		KRAB	214..274	CDD:214630	19/107 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..274		15/84 (18%)
		zf-C2H2	314..336	CDD:395048	4/21 (19%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		zf-H2C2_2	329..351	CDD:463886	10/21 (48%)
		zf-C2H2	342..364	CDD:395048	8/21 (38%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		COG5048	<368..515	CDD:227381	36/88 (41%)
		C2H2 Zn finger	372..392	CDD:275368	9/19 (47%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368
		zf-C2H2	508..530	CDD:395048
		C2H2 Zn finger	510..530	CDD:275368