Protein Alignment CG4854 and ZNF75D

DIOPT Version :10

• Sequence 1: NP_650860.1
• Gene: CG4854 / 42391
• FlyBaseID: FBgn0038766
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_009062.2
• Gene: ZNF75D / 7626
• HGNCID: 13145
• Length: 510
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 83/329 - (25%)
• Similarity: 140/329 - (42%)
• Gaps: 83/329 - (25%)

  Fly    16 LVQPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRAALKLRSLCQQTEKDLKE 80
            |:.|:..||:..|.         ..|..||. :|                   .|....||.|..
Human   226 LILPESLSLLTFED---------VAVYFSEE-EW-------------------QLLNPLEKTLYN 261

  Fly    81 QKLQEINIEIVHDEQETKKKTESRDLSKNEATGSDSELEYEYLDSYDVTLESSEDVACSADELVS 145
            ..:|:|...::           |..|.....||:|          :.:::.:|| :..|..| ||
Human   262 DVMQDIYETVI-----------SLGLKLKNDTGND----------HPISVSTSE-IQTSGCE-VS 303

  Fly   146 IEPAISAPEESVYSLSP-------------------KPVTFEDE-----------DSGQAASFTC 180
            .:..:...::::...:|                   ||.|.:.|           .:|: ..|.|
Human   304 KKTRMKIAQKTMGRENPGDTHSVQKWHRAFPRKKRKKPATCKQELPKLMDLHGKGPTGE-KPFKC 367

  Fly   181 NICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFAD 245
            ..|...:.....|..|.::|:.:||::|:.|.:|||.:..|.:|..||.|.:||:|.:|...|:.
Human   368 QECGKSFRVSSDLIKHHRIHTGEKPYKCQQCDRRFRWSSDLNKHFMTHQGIKPYRCSWCGKSFSH 432

  Fly   246 PSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEK 310
            .:....||||||.|:|:||:.|.:.|..::.|..|.:|||||:|::|..|:::||:......|:|
Human   433 NTNLHTHQRIHTGEKPFKCDECGKRFIQNSHLIKHQRTHTGEQPYTCSLCKRNFSRRSSLLRHQK 497

  Fly   311 SHKR 314
            .|:|
Human   498 LHRR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4854	NP_650860.1	zf-AD	12..>57	CDD:214871	9/40 (23%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	201..>258	CDD:227381	22/56 (39%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:463886	9/22 (41%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	251..271	CDD:463886	11/19 (58%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
ZNF75D	NP_009062.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		SCAN	45..133	CDD:460417
		KRAB	234..275	CDD:460171	13/80 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..342		2/28 (7%)
		zf-C2H2	365..387	CDD:395048	5/21 (24%)
		C2H2 Zn finger	367..387	CDD:275368	4/19 (21%)
		COG5048	<378..>492	CDD:227381	44/113 (39%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)