DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4854 and ZNF66

DIOPT Version :9

Sequence 1:NP_650860.1 Gene:CG4854 / 42391 FlyBaseID:FBgn0038766 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_001342126.2 Gene:ZNF66 / 7617 HGNCID:13135 Length:573 Species:Homo sapiens


Alignment Length:274 Identity:79/274 - (28%)
Similarity:121/274 - (44%) Gaps:32/274 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 LCQQTEKDL-KEQKLQEINIEIV--------HDEQETKKKTESRDLSKNEATGSDSELEYEYLDS 125
            ||....:|| .||.:::...:::        ||..:.||..||.|..|....|      |..|:.
Human    77 LCSHFNQDLWPEQSIKDSFQKLILRRHKKCGHDNLQLKKGCESVDKCKVHKRG------YNGLNQ 135

  Fly   126 YDVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTFED--EDSGQAASFT--------- 179
            . :|...|:...|.....| .....:.....:......|..|.:  :...::::||         
Human   136 C-LTTTQSKMFQCDKHGKV-FHQFSNTNRHKIRHTGKNPCKFTECGKAFNRSSTFTTHKKIHTGE 198

  Fly   180 ----CNICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCD 240
                |..|...::....||.|..:|:.:|.::||.|.|.|.::..|..|...|||.:||||:.|.
Human   199 KPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCEDCGKAFNRSSNLTTHKKIHTGEKPYKCEECG 263

  Fly   241 SRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHK 305
            ..|...|....|:||||.|:|||||.|.:.|.|.:.|..|...||||:|:.|:.|.|:|:...|.
Human   264 KAFKRSSILTTHKRIHTGEKPYKCEECGKVFKYLSSLSTHKIIHTGEKPYKCEECGKAFNWSSHL 328

  Fly   306 NSHEKSHKRTKEVK 319
            .:|::.|...|..|
Human   329 TTHKRIHTGEKPYK 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4854NP_650860.1 zf-AD 12..>57 CDD:285071
C2H2 Zn finger 180..200 CDD:275368 5/19 (26%)
zf-H2C2_2 193..217 CDD:290200 10/23 (43%)
COG5048 201..>258 CDD:227381 22/56 (39%)
C2H2 Zn finger 208..228 CDD:275368 7/19 (37%)
zf-H2C2_2 221..244 CDD:290200 10/22 (45%)
C2H2 Zn finger 236..256 CDD:275368 6/19 (32%)
zf-H2C2_2 251..273 CDD:290200 13/21 (62%)
C2H2 Zn finger 264..284 CDD:275368 7/19 (37%)
zf-H2C2_2 277..301 CDD:290200 11/23 (48%)
C2H2 Zn finger 292..312 CDD:275368 6/19 (32%)
ZNF66NP_001342126.2 KRAB 4..64 CDD:214630
C2H2 Zn finger 147..167 CDD:275368 2/20 (10%)
C2H2 Zn finger 176..195 CDD:275368 2/18 (11%)
COG5048 199..569 CDD:227381 54/144 (38%)
C2H2 Zn finger 203..223 CDD:275368 5/19 (26%)
C2H2 Zn finger 231..251 CDD:275368 7/19 (37%)
C2H2 Zn finger 259..279 CDD:275368 6/19 (32%)
C2H2 Zn finger 287..307 CDD:275368 7/19 (37%)
C2H2 Zn finger 315..335 CDD:275368 6/19 (32%)
C2H2 Zn finger 343..363 CDD:275368 79/274 (29%)
C2H2 Zn finger 371..391 CDD:275368
C2H2 Zn finger 399..419 CDD:275368
C2H2 Zn finger 427..447 CDD:275368
C2H2 Zn finger 455..475 CDD:275368
C2H2 Zn finger 483..503 CDD:275368
C2H2 Zn finger 511..531 CDD:275368
C2H2 Zn finger 539..559 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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